Marc G. B.
- Country
- The Netherlands
- Department
- Surgery
Research Overview
- Evaluation of Cefuroxime and Metronidazole in Reducing Infectious Complications Post-Pancreatoduodenectomy in High-Risk Patients: A Randomized Controlled Trial
- Evaluation of Neoadjuvant FOLFIRINOX Versus Gemcitabine-Based Chemoradiotherapy in Borderline Resectable Pancreatic Cancer
- Comparison of Perioperative and Adjuvant mFOLFIRINOX Regimens in Patients with Resectable Non-Metastatic Pancreatic Cancer
Data & Insights
Has run more than one trial at 20 of 61 partner sites.
Specializations
Pancreatic and Periampullary Oncology
The investigator’s surgical program concentrates on pancreatic cancer ranging from resectable to borderline‑resectable disease, with integrated multimodal strategies.
- Borderline resectable pancreatic cancer
- Pancreatic ductal adenocarcinoma (PDAC)
- Neoadjuvant chemotherapy for pancreatic tumors
- Pancreatoduodenectomy with high‑risk biliary contamination
- Post‑operative outcomes after pancreatic surgery
Clinical activity is anchored at Amsterdam UMC’s surgical department.
Colorectal Cancer and Peritoneal Disease
In colorectal oncology, the focus is on advanced disease patterns, especially peritoneal dissemination and metastatic spread.
- Colorectal liver metastases
- Peritoneal metastases from colorectal origin (PCI‑score 1‑20)
- Adjuvant therapy guided by circulating tumor DNA
- Resectable colorectal rectal metastases without extra‑hepatic disease
- Early‑stage rectal cancer (cT1‑3abN0‑M0)
Research integrates surgical resection with systemic treatment pathways.
Metabolic Liver Disease
The investigator participates in trials addressing chronic liver injury linked to metabolic dysfunction, notably non‑alcoholic steatohepatitis.
- Metabolic dysfunction‑associated steatohepatitis (MASH) with fibrosis
- NAFLD progression to cirrhosis
- Pharmacologic reduction of hepatic fibrosis
- Biomarker‑driven patient stratification in liver disease
- Long‑term safety of liver‑targeted agents
Efforts aim to translate metabolic insights into therapeutic options.
Cardiovascular Disease
Cardiovascular research centers on atherosclerotic burden and heart failure phenotypes, including high‑risk cohorts.
- Atherosclerotic cardiovascular disease (ASCVD)
- Acute myocardial infarction with cardiogenic shock
- Heart failure with reduced ejection fraction
- Genetic carriers of dilated cardiomyopathy variants
- Prevention of left‑ventricular dysfunction in asymptomatic carriers
Clinical investigations are conducted within the surgical and cardiovascular units of Amsterdam UMC.
Autoimmune and Inflammatory Medicine
Work in autoimmune disorders emphasizes gastrointestinal and systemic inflammation, such as inflammatory bowel disease.
- Moderately to severely active ulcerative colitis
- Moderately to severely active Crohn’s disease
- Axial spondyloarthritis
- Rheumatoid arthritis without prior cardiovascular disease
- Autoimmune vasculitis (ANCA‑associated)
Therapeutic focus includes biologic and targeted small‑molecule approaches.
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