Mar B.
- Country
- The Netherlands
- Department
- Hematology
Research Overview
- Blinatumomab and Combination Therapy Versus Standard of Care in Older Adults With Newly Diagnosed Philadelphia-Negative B-Cell Precursor Acute Lymphoblastic Leukemia
- Efficacy and Safety Evaluation of Epcoritamab, Venetoclax, and Lenalidomide in Relapsed/Refractory Chronic Lymphocytic Leukemia and Richter's Syndrome
- Evaluation of BGB-16673 Versus Pirtobrutinib in Relapsed/Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Patients
Data & Insights
Has run more than one trial at 32 of 153 partner sites.
Specializations
Hematologic Malignancies
Clinical research activity includes a broad focus on lymphoma, leukemia, and plasma cell disorders, with interest in aggressive and relapsed/refractory blood cancers as well as disease settings requiring novel immune-based and targeted treatment options.
- Diffuse large B-cell lymphoma
- Acute myeloid leukemia
- Multiple myeloma
- Myelodysplastic syndrome
- Hodgkin lymphoma
The therapeutic portfolio also extends to chronic lymphocytic leukemia, mantle cell lymphoma, and myelofibrosis, reflecting involvement in advanced hematology and innovative treatment development.
Solid Tumors and Thoracic Oncology
Research interests strongly include non-small cell lung cancer and small cell lung cancer, alongside a wider range of advanced solid tumors spanning gastrointestinal, genitourinary, and head and neck cancers.
- Non-small cell lung cancer
- Small cell lung cancer
- Head and neck squamous cell carcinoma
- Colorectal cancer
- Ovarian cancer
Additional involvement covers melanoma, prostate cancer, urothelial cancer, and esophageal cancer, with attention to biomarker-defined and metastatic disease.
Autoimmune and Inflammatory Disease
Clinical trial activity includes immune-mediated disorders such as inflammatory bowel disease, Crohn’s disease, ulcerative colitis, and hidradenitis suppurativa, with additional interest in chronic inflammatory skin and rheumatic conditions.
- Crohn’s disease
- Ulcerative colitis
- Hidradenitis suppurativa
- Rheumatoid arthritis
- Systemic lupus erythematosus
The therapeutic scope also includes primary Sjögren’s disease, polymyalgia rheumatica, psoriasis, and bullous pemphigoid, supporting work in immune modulation and inflammatory disease control.
Kidney and Transplant Medicine
Research activity shows a strong commitment to chronic kidney disease, IgA nephropathy, autosomal dominant polycystic kidney disease, and proteinuria, with interest in preserving renal function and addressing progressive kidney injury.
- Chronic kidney disease
- IgA nephropathy
- Autosomal dominant polycystic kidney disease
- Kidney transplant rejection
- Prophylaxis against renal transplant rejection
Additional involvement includes kidney transplantation, renal failure, and glomerulonephritis, along with studies addressing transplant compatibility and graft outcomes.
Cardiovascular and Amyloid Disorders
Clinical interests also extend to heart failure, atrial fibrillation, coronary artery disease, and myocardial infarction, with a notable focus on cardiovascular risk reduction and cardiometabolic disease.
- Heart failure
- Atrial fibrillation
- Coronary artery disease
- Transthyretin amyloid cardiomyopathy
- AL amyloidosis
Further therapeutic interest is seen in pulmonary hypertension, stroke prevention, and systemic amyloidosis, linking cardiovascular care with complex multisystem disease management.
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