Manuel L. M.
- Country
- Spain
- Department
- Nephrology
Research Overview
- A Phase I Dose Escalation Study of Bispecific Antibodies in Adult Patients with Lupus Nephritis
- Phase I/IIa Multicenter Study of TranspoCART19 CD19 CAR‑T Cell Therapy in Patients with Refractory Lupus Nephritis: Safety and Preliminary Efficacy
- A Phase 2b, Randomized, Controlled Double-blind, Multicenter Study Comparing the Efficacy and Safety of Zetomipzomib (KZR-616) 30 mg or 60 mg with Placebo in Patients with Active Lupus Nephritis
Data & Insights
Has run more than one trial at 19 of 115 partner sites.
Specializations
Nephrology and Renal Disease
Clinical research interest includes chronic kidney disease, IgA nephropathy, primary membranous nephropathy, focal segmental glomerulosclerosis, Alport syndrome, autosomal dominant polycystic kidney disease, and proteinuric glomerular diseases, with attention to both native kidney disease and renal allograft care.
- Chronic kidney disease
- IgA nephropathy
- Primary membranous nephropathy
- Proteinuria
- Renal transplantation
Additional activity extends to kidney function in systemic disease, albuminuria, nephrotic-range proteinuria, and secondary hyperparathyroidism associated with advanced renal impairment.
Cardiovascular and Thromboembolic Medicine
The investigator is involved in studies of atherosclerotic cardiovascular disease, heart failure, atrial fibrillation, myocardial infarction, stroke prevention, venous thromboembolism, and pulmonary embolism, reflecting a strong interest in vascular risk and cardiorenal overlap.
- Atherosclerotic cardiovascular disease
- Heart failure
- Atrial fibrillation
- Venous thromboembolism
- Acute coronary syndrome
Research also includes dyslipidemia, hypertriglyceridemia, lipoprotein(a), and genetic cardiomyopathy, alongside prevention-focused work in high-risk cardiometabolic populations.
Oncology and Hematologic Malignancies
Clinical trial involvement spans breast cancer, non-small cell lung cancer, renal cell carcinoma, urothelial carcinoma, prostate cancer, ovarian cancer, and gastrointestinal malignancies, as well as multiple lymphoid and myeloid neoplasms.
- Breast cancer
- Non-small cell lung cancer
- Renal cell carcinoma
- Multiple myeloma
- Diffuse large B-cell lymphoma
Therapeutic interests also cover acute leukemias, myelodysplastic syndromes, lymphoma, myeloma, and solid tumors with molecularly defined targets, including HER2, EGFR, KRAS, and BRCA-related disease.
Autoimmune, Inflammatory, and Pulmonary Disorders
Research activity includes systemic lupus erythematosus, psoriatic arthritis, Crohn's disease, ulcerative colitis, Behçet’s disease, systemic sclerosis, and sarcoidosis, with emphasis on immune-mediated inflammation across multiple organ systems.
- Systemic lupus erythematosus
- Crohn's disease
- Ulcerative colitis
- Psoriatic arthritis
- Pulmonary sarcoidosis
Additional interests include interstitial lung disease, idiopathic pulmonary fibrosis, asthma, chronic obstructive pulmonary disease, and allergic rhinitis, linking respiratory inflammation with systemic immune disease.
Metabolic, Hepatic, and Neurologic Conditions
Clinical research also addresses metabolic dysfunction-associated steatotic liver disease, nonalcoholic steatohepatitis, primary biliary cholangitis, obesity, type 2 diabetes, and migraine, alongside selected neurodegenerative and neurologic disorders.
- Nonalcoholic steatohepatitis
- Primary biliary cholangitis
- Obesity
- Type 2 diabetes
- Migraine
Further involvement includes Parkinson’s disease, Alzheimer’s disease, schizophrenia, and epilepsy, broadening the therapeutic scope into chronic neurologic and psychiatric care.
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