Manon S.
- Country
- The Netherlands
- Department
- Internal Medicine
Research Overview
- Efficacy of Obicetrapib and Obicetrapib plus Ezetimibe in Reducing LDL-C in Patients with Type 2 Diabetes and/or Metabolic Syndrome
- Evaluation of Olpasiran in Reducing First Major Cardiovascular Events in Patients with Elevated Lipoprotein(a) Levels: A Double-Blind, Randomized, Placebo-Controlled Study
Data & Insights
Has run more than one trial at 3 of 331 partner sites.
Specializations
Cardiovascular medicine
Clinical research in cardiovascular disease is a central area of interest, with involvement in trials addressing acute myocardial infarction, heart failure, atrial fibrillation, and atherosclerotic cardiovascular disease. The portfolio also includes work in vascular risk reduction, stroke prevention, and management of patients with elevated lipoprotein(a) and hypertriglyceridemia.
- Acute coronary syndrome
- Heart failure
- Atrial fibrillation
- Stroke prevention
Research activity also extends to cardiometabolic risk, including obesity-linked cardiovascular outcomes and prevention strategies for high-risk patients.
Oncology
Therapeutic interests in oncology span both solid tumors and hematologic malignancies, with studies in breast cancer, prostate cancer, colorectal cancer, gastric cancer, and esophageal cancer. Hematology-focused work includes diffuse large B-cell lymphoma, follicular lymphoma, multiple myeloma, and non-Hodgkin lymphoma.
- Breast neoplasms
- Colorectal cancer
- Prostate cancer
- Lymphoma
Additional activity includes treatment strategies for HER2-positive disease, triple negative breast cancer, and targeted anticancer therapy in genomically selected tumors.
Respiratory and immunologic disorders
Research involvement includes chronic obstructive pulmonary disease, severe asthma with eosinophilic phenotype, chronic spontaneous urticaria, and respiratory tract infection. The portfolio also covers immune-mediated conditions such as multiple sclerosis and idiopathic nephrotic syndrome.
- Severe asthma
- Chronic spontaneous urticaria
- Chronic obstructive pulmonary disease
- Multiple sclerosis
These studies reflect interest in inflammatory disease control, symptom reduction, and long-term disease management across pulmonary and immune-related conditions.
Gastrointestinal and hepatobiliary oncology
Clinical trial activity includes rectal cancer, colon cancer, metastatic colorectal cancer, colorectal liver metastases, pancreatic cancer, and gastric adenocarcinoma. The research landscape also encompasses organ-preserving strategies in early rectal cancer and treatment optimization in locally advanced and metastatic gastrointestinal malignancies.
- Rectal cancer
- Metastatic colorectal cancer
- Pancreatic cancer
- Gastric cancer
Work in this area also includes hepatic arterial infusion approaches and combined modality treatment concepts for advanced digestive tract tumors.
Metabolic and endocrine disorders
Research interests include obesity, type 2 diabetes, polycystic ovary syndrome, unexplained subfertility, and myopia. The portfolio also covers lipid disorders and metabolic risk states linked to cardiovascular and renal outcomes.
- Obesity
- Type 2 diabetes
- Polycystic ovary syndrome
- Subfertility
Additional activity includes lipid-lowering therapy, prevention of metabolic complications, and treatment strategies for obesity-associated disease.
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