Manon D.
- Country
- France
- Department
- 500: Hemato-Immuno-Oncologie Pediatrique
Research Overview
Data & Insights
Has run more than one trial at 0 of 5 partner sites.
Specializations
Pediatric Hemato‑Oncology
The investigator leads studies on malignant blood disorders in children and adolescents, addressing both acute and chronic entities that require intensive multimodal therapy.
- Acute Lymphoblastic Leukemia
- Acute Myeloid Leukemia
- Chronic Lymphocytic Leukemia
- Myelodysplastic Syndrome
- Hodgkin Lymphoma
- Non‑Hodgkin Lymphoma
Research emphasizes risk‑adapted treatment, transplant eligibility, and long‑term survivorship outcomes.
Autoimmune and Systemic Inflammatory Diseases
Focused on immune‑mediated disorders that affect multiple organ systems, the work integrates immunophenotyping with targeted therapeutic strategies.
- Systemic Lupus Erythematosus
- Primary Sjögren’s Syndrome
- ANCA‑Associated Vasculitis
- Immune Thrombocytopenia
- Idiopathic Inflammatory Myopathies
- Psoriatic Arthritis
Efforts target disease activity reduction, organ protection, and biomarker‑driven patient stratification.
Rare Genetic and Amyloid Disorders
Investigations address hereditary protein‑misfolding conditions and genetically driven kidney diseases that lack approved disease‑modifying options.
- Hereditary Transthyretin Amyloidosis
- APOL1‑Mediated Kidney Disease
- Familial Amyloid Polyneuropathy
- Alpha‑1 Antitrypsin Deficiency‑Associated Liver Disease
- Primary Immunodeficiency Syndromes
Clinical programs aim to evaluate novel molecular therapies and assess functional outcomes.
Infectious and Mycobacterial Diseases
Studies encompass chronic pulmonary infections and opportunistic pathogens in immunocompromised hosts, with an emphasis on antimicrobial stewardship.
- Nontuberculous Mycobacterial Lung Infection
- Herpes Simplex Virus Reactivation
- Adenovirus Viremia
- Invasive Fungal Infections
- Multidrug‑Resistant Gram‑Negative Bacterial Colonization
Projects evaluate diagnostic algorithms, prophylactic regimens, and therapeutic optimization.
Cardiovascular and Metabolic Medicine
Research addresses acute coronary events, heart failure phenotypes, and metabolic disorders that intersect with oncologic and immunologic care.
- Acute Coronary Syndrome
- Heart Failure with Preserved Ejection Fraction
- Hypertension
- Type 2 Diabetes Mellitus
- Obesity‑Related Cardiovascular Risk
Efforts focus on integrated risk assessment, lifestyle interventions, and emerging cardiometabolic therapeutics.
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