Manon B.
- Country
- The Netherlands
- Department
- Neonatalogy
Research Overview
- Phase II Randomized, Placebo‑Controlled Trial of Intranasal Bone‑Marrow Derived Mesenchymal Stromal Cells (Remestemcel) in Neonates with Hypoxic‑Ischemic Brain Injury
- Evaluation of Darbepoetin Alfa in Reducing Brain Injury in Neonates with Perinatal Arterial Ischemic Stroke: A Randomized, Double-Blind, Placebo-Controlled Study
- Evaluation of Allopurinol Sodium for Cerebral and Cardiac Protection in Neonates with Critical Congenital Heart Disease Undergoing Cardiopulmonary Bypass
Data & Insights
Has run more than one trial at 1 of 3 partner sites.
Specializations
Neonatal medicine and perinatal care
Clinical research activity in neonatology with attention to conditions affecting newborns and very early life, including apnea of prematurity, brain injury in neonates, hypoxic-ischemic encephalopathy, and chronic lung disease in extremely premature infants.
- Preterm infant respiratory support
- Neonatal brain injury
- Congenital heart disease in newborns
- Perinatal ischemic injury
Research interests also include neonatal complications linked to prematurity and early developmental vulnerability.
Pediatric and developmental disorders
Active involvement in therapeutic studies for childhood conditions such as acute lymphoblastic leukaemia, spinal muscular atrophy, osteogenesis imperfecta, mucopolysaccharidosis type I, and primary immunodeficiency diseases.
- Childhood hematologic malignancies
- Inherited neuromuscular disease
- Rare skeletal disorders
- Inborn errors of metabolism
Therapeutic focus extends to pediatric populations requiring specialized long-term disease management.
Maternal-fetal and pregnancy-related conditions
Clinical trial involvement spans hypertensive disorders of pregnancy, preterm preeclampsia, HELLP syndrome, and pregnancy in HIV infection, reflecting interest in conditions that affect maternal and fetal outcomes.
- Pregnancy complications
- Maternal hypertension
- Fetal and neonatal risk reduction
- Antiretroviral pharmacokinetics in pregnancy
Work in this area also includes disorders with direct implications for delivery planning and newborn health.
Immune-mediated and inflammatory disease
Research activity includes treatment-focused studies in atopic dermatitis, food allergy, Crohn’s disease, ulcerative colitis, juvenile idiopathic arthritis, and systemic lupus erythematosus.
- Allergic disease
- Inflammatory bowel disease
- Autoimmune rheumatic disease
- Immune dysregulation
The therapeutic landscape also covers rare immune-mediated disorders and chronic inflammatory syndromes.
Long-term safety and innovative therapies
Investigator activity includes follow-up and treatment evaluation in gene-modified T-cell therapies, CAR T-cell approaches, and other advanced interventions, with attention to safety monitoring and sustained clinical benefit.
- Cell-based immunotherapy
- Gene therapy follow-up
- Rare disease treatment innovation
- Paediatric treatment safety
Additional involvement includes therapies for severe respiratory, cardiovascular, and metabolic conditions in vulnerable patient groups.
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