Malvina L.
- Country
- Greece
- Department
- 2nd Department of Internal Medicine
Research Overview
Data & Insights
Has run more than one trial at 0 of 18 partner sites.
Specializations
Cardiovascular Inflammation & Heart Failure
The investigator concentrates on IL-6 inhibition to mitigate systemic inflammation in patients with heart failure and preserved or mildly reduced ejection fraction, particularly when obesity is present.
- IL-6 pathway modulation
- ziltivekimab therapy
- systemic inflammation biomarkers
- HFpEF/HFmrEF management
- obesity‑related cardiac risk
These efforts aim to lower the incidence of major adverse cardiovascular events in this high‑risk population.
Acute Myocardial Infarction Therapeutics
Research targets early intervention for acute myocardial infarction, including self‑administered agents and rapid anti‑inflammatory strategies to improve outcomes after ST‑elevation and non‑ST‑elevation events.
- selatogrel self‑administration
- early IL‑6 inhibition post‑AMI
- major adverse cardiovascular event reduction
- ST‑elevation and non‑ST‑elevation MI
- patient‑initiated treatment strategies
The work integrates novel agents with standard reperfusion care to enhance survival and functional recovery.
Sepsis and Severe Infection Immunomodulation
The focus is on immunologic endotypes such as IFNγ‑driven sepsis, employing monoclonal antibodies to modulate the host response and reduce mortality.
- emapalumab for IFNγ‑driven sepsis
- endotype‑guided therapy
- biomarker‑guided dosing
- mortality risk reduction
- severe infection management
This personalized approach seeks to improve outcomes in patients meeting Sepsis‑3 criteria.
Chronic Respiratory Infections
Investigations address bronchiectasis with chronic Pseudomonas aeruginosa colonization, evaluating novel inhaled therapies to curb pulmonary exacerbations.
- Bronchiectasis management
- chronic Pseudomonas aeruginosa colonization
- AZD0292 efficacy
- pulmonary exacerbation reduction
- antibiotic stewardship in respiratory disease
Outcomes aim to enhance quality of life and reduce healthcare utilization for affected individuals.
Ocular Hypertension & Glaucoma
The investigator evaluates fixed‑dose combinations for lowering intraocular pressure in patients with open‑angle glaucoma or ocular hypertension, comparing generic formulations to established products.
- brinzolamide/timolol fixed‑dose combination
- intraocular pressure control
- open‑angle glaucoma
- ocular hypertension treatment
- comparative efficacy studies
These studies contribute to optimizing therapeutic options for preserving visual function.
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