Makarios E.
- Country
- Greece
- Department
- 2nd Department of Obstetrics and Gynecology
Research Overview
Data & Insights
Has run more than one trial at 0 of 17 partner sites.
Specializations
Gynecologic Oncology
Investigator concentrates on malignancies of the female reproductive system, including ovarian cancer, endometrial cancer, fallopian tube neoplasms and peritoneal neoplasms.
- Platinum‑resistant ovarian cancer
- High‑grade serous ovarian carcinoma
- Recurrent endometrial carcinoma
- Primary peritoneal carcinoma
These efforts target innovative therapeutic strategies for advanced or recurrent disease.
Breast Cancer Therapeutics
Research emphasis lies on hormone‑driven and triple‑negative disease, such as ER+/HER2‑negative breast cancer, triple‑negative breast cancer and hormone receptor‑positive breast cancer.
- ESR1‑mutated advanced breast cancer
- Hormone‑resistant breast cancer
- HER2‑negative metastatic breast cancer
- Adjuvant endocrine therapy optimization
The work seeks to expand effective options across disease stages and molecular subtypes.
Gastrointestinal Oncology
Focus includes malignancies of the digestive tract, notably colorectal cancer, pancreatic ductal adenocarcinoma and related treatment‑related complications.
- Chemotherapy‑induced thrombocytopenia
- Metastatic colorectal cancer
- KRAS‑mutated colorectal cancer
- Advanced pancreatic cancer
These studies aim to improve survival and manage therapy‑associated toxicities.
Thoracic and Renal Oncology
Investigator engages in lung and kidney cancer research, covering non‑small cell lung cancer and renal cell carcinoma.
- EGFR‑mutated NSCLC
- PD‑L1‑positive NSCLC
- Advanced renal cell carcinoma
- Combination immunotherapy regimens
Efforts are directed toward targeted and immune‑based treatment advances.
Obstetric and Maternal Health
Research also addresses pregnancy‑related conditions, particularly preeclampsia prevention.
- Low‑dose aspirin for preeclampsia prophylaxis
- Twin pregnancy complications
- Early‑onset preeclampsia mitigation
- Maternal cardiovascular risk reduction
These initiatives aim to improve maternal outcomes and reduce pregnancy‑associated morbidity.
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