Madeleine A.
- Country
- France
- Department
- Centre d'lnvestigation Clinique pediatrique
Research Overview
- Efficacy and Safety Evaluation of Odevixibat in Pediatric Biliary Atresia Post-Kasai Hepatoportoenterostomy: A Double-Blind, Randomized, Placebo-Controlled Trial
- An Open-label Extension Study to Evaluate Long-term Efficacy and Safety of Odevixibat (A4250) in Children with Biliary Atresia (BOLD-EXT)
- Long-term Safety and Efficacy Evaluation of Odevixibat in Alagille Syndrome Patients Completing Study A4250-012 (ASSERT)
Data & Insights
Has run more than one trial at 16 of 24 partner sites.
Specializations
Pediatric Hepatology
The investigator specializes in treating rare hepatobiliary disorders, with particular emphasis on Alagille Syndrome and Biliary Atresia in pediatric populations. Their research encompasses innovative therapeutic approaches for managing these challenging conditions.
- Alagille Syndrome Management
- Biliary Atresia Treatment
- Pediatric Liver Disorders
Their work focuses on evaluating long-term therapeutic interventions for chronic liver conditions in children.
Surgical Outcomes
The investigator studies post-surgical outcomes in children who have undergone Kasai hepatoportoenterostomy, examining factors that influence native liver survival and long-term prognosis.
- Post-Surgical Care
- Native Liver Survival
- Long-term Outcome Assessment
Their research extends to monitoring and improving post-operative therapeutic interventions in pediatric liver surgery.
Symptom Management
The investigator explores therapeutic approaches for managing symptoms associated with hepatobiliary disorders, particularly focusing on pruritus control and quality of life improvements in pediatric patients.
- Pruritus Treatment
- Quality of Life Assessment
- Long-term Safety Monitoring
Their work emphasizes sustained therapeutic effects and safety in long-term treatment protocols.
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