Maaike L.
- Country
- The Netherlands
- Department
- Pediatric Oncology
Research Overview
- Revumenib in Combination with Fludarabine and Cytarabine for Pediatric Refractory or Relapsed KMT2A-r, NUP98-r, or NPM1-mut Acute Myeloid Leukemia
- Asciminib in Pediatric Philadelphia-Positive Chronic Myeloid Leukemia in Chronic Phase With or Without T315I Mutation: Phase II Safety and Efficacy Study
- Phase 1 Study of Ziftomenib with Chemotherapy in Pediatric Relapsed/Refractory KMT2A-r, NUP98-r, or NPM1-m Acute Leukemia
Data & Insights
Has run more than one trial at 10 of 35 partner sites.
Specializations
Pediatric Hematologic Oncology
The investigator specializes in treating children with acute leukemia, focusing particularly on challenging cases involving relapsed and refractory conditions. Their expertise extends to various forms of blood cancers, including acute myeloid leukemia, mixed phenotype acute leukemia, and acute lymphocytic leukemia.
- Pediatric Leukemia Treatment
- Refractory Blood Cancer Management
- Advanced Therapeutic Approaches
Their work involves investigating innovative combination therapies for young patients with specific genetic markers in leukemia.
Molecular Oncology
The investigator demonstrates particular interest in leukemia cases involving specific genetic alterations, including KMT2A rearrangements, NUP98 rearrangements, and NPM1 mutations. Their research focuses on targeted therapeutic approaches for these molecular subtypes.
- Genetic Markers in Leukemia
- Molecular Profiling
- Targeted Therapy Development
Their expertise encompasses the identification and treatment of genetically defined leukemia subtypes in pediatric populations.
Therapeutic Development
The investigator focuses on developing and evaluating novel therapeutic combinations for treating resistant forms of pediatric leukemia. Their work includes studying pharmacokinetics and determining optimal dosing strategies for combination treatments.
- Combined Therapy Approaches
- Safety Assessment
- Drug Development
Their research aims to establish effective treatment protocols for children with difficult-to-treat leukemia variants.
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