M. C.
- Country
- The Netherlands
- Department
- Gynaecology
Research Overview
Data & Insights
Has run more than one trial at 0 of 41 partner sites.
Specializations
Gynecologic Oncology
Focuses on malignant and premalignant conditions of the female reproductive tract, including vulvar high‑grade squamous intraepithelial lesion.
- Adjuvant nonavalent HPV vaccination for vulvar HSIL
- Surgical excision combined with immunoprophylaxis
- Long‑term recurrence monitoring
Studies aim to reduce lesion progression and improve disease‑free outcomes.
Breast Cancer Therapeutics
Investigates targeted and endocrine strategies for triple negative breast cancer, HER2‑positive breast cancer, and HR+/HER2‑negative metastatic breast cancer.
- Dual HER2 blockade with trastuzumab and pertuzumab
- CDK4/6 inhibition combined with aromatase inhibitors
- Immune checkpoint inhibition with pembrolizumab in residual disease
Emphasis on improving event‑free and overall survival across molecular subtypes.
Gastrointestinal Oncology
Addresses treatment optimization for locally advanced rectal cancer, gastric adenocarcinoma, and peritoneal dissemination of stomach tumors.
- Preoperative chemotherapy regimens for resectable gastric cancer
- Neoadjuvant chemoradiotherapy for rectal cancer
- Cytoreductive surgery with HIPEC for peritoneal dissemination
Goal is to enhance resection rates and prolong survival.
Hematologic Oncology
Focuses on novel therapeutic sequences for multiple myeloma.
- Induction with daratumumab‑lenalidomide‑dexamethasone followed by treatment‑free interval
- Maintenance strategies post‑induction
- Biomarker‑driven response assessment
Research seeks to balance disease control with quality of life.
Thrombosis Prophylaxis
Evaluates risk‑adapted prevention of venous thromboembolism in orthopedic surgery patients.
- Individualized prophylaxis versus standard regimen
- Assessment of bleeding complications
- Stratification by low, intermediate, and high VTE risk
Findings aim to refine prophylactic guidelines.
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