Lynn Sophie Z. B.
- Country
- Germany
- Department
- Berlin Institute of Health Department of Ophthalmology
Research Overview
Data & Insights
Has run more than one trial at 0 of 4 partner sites.
Specializations
Retinal and Macular Disorders
Investigates degenerative and vascular pathologies of the retina and macula to maintain visual acuity.
- Age-related macular degeneration
- Diabetic macular edema
- Exudative macular degeneration
- Retinal vein occlusion
Therapeutic programs explore anti‑VEGF biologics, complement pathway inhibitors, and sustained‑release drug delivery.
Autoimmune Ocular Inflammation
Targets immune‑mediated inflammatory eye diseases, linking systemic autoimmunity to ocular outcomes.
- Uveitis
- Anterior scleritis
- Posterior uveitis
- Vogt‑Koyanagi‑Harada disease
Studies assess cytokine‑targeted agents, B‑cell depleting therapies, and steroid‑sparing regimens.
Ocular Oncology
Focuses on malignant neoplasms of the eye and peri‑ocular tissues, emphasizing early detection and targeted treatment.
- Uveal melanoma
- Conjunctival squamous cell carcinoma
- Intraocular lymphoma
- Retinoblastoma
Clinical trials evaluate checkpoint inhibitors, small‑molecule kinase inhibitors, and localized radiotherapy.
Systemic Autoimmune Diseases with Ocular Involvement
Examines how systemic autoimmune disorders manifest in the eye, guiding interdisciplinary management.
- Systemic lupus erythematosus
- Sjögren’s syndrome
- Rheumatoid arthritis‑associated keratopathy
- Granulomatosis with polyangiitis
Research integrates ophthalmic imaging, serologic biomarkers, and systemic immunomodulatory therapy.
Emerging Gene and Cell Therapies for Vision Restoration
Develops innovative molecular approaches to treat inherited and acquired retinal degeneration.
- Gene replacement for RPE65‑related disease
- CRISPR‑based editing for inherited retinopathies
- Stem‑cell derived retinal pigment epithelium transplantation
- Optogenetic vision prosthesis
Trials assess safety, functional integration, and long‑term visual outcomes in adult and pediatric cohorts.
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