Lucia T. L.
- Country
- Spain
- Department
- Gastroenterology
Research Overview
Data & Insights
Has run more than one trial at 0 of 11 partner sites.
Specializations
Metabolic Liver Disease & Non‑Alcoholic Steatohepatitis
The investigator concentrates on Non‑Alcoholic Steatohepatitis (NASH) and related metabolic liver disorders, addressing the transition from hepatic steatosis to fibrosis and eventual cirrhosis in patients with obesity, type 2 diabetes and dyslipidaemia.
- Pathophysiology of hepatic steatosis
- Therapeutic targets for insulin resistance
- Biomarkers of disease progression
- Impact of metabolic dysfunction‑associated steatohepatitis on cardiovascular risk
Research is conducted at Fundacion Para La Investigacion Biomedica Del Hospital Universitario La Paz in Madrid, Spain.
Inflammatory Bowel Disease
Focused on chronic intestinal inflammation, the work spans Crohn’s Disease and Ulcerative Colitis, emphasizing mucosal healing, disease remission and quality‑of‑life outcomes across adult and paediatric populations.
- Novel biologics for mucosal healing
- Microbiome modulation strategies
- Clinical endpoints for sustained remission
- Pediatric IBD management protocols
Studies integrate multidisciplinary gastroenterology expertise within the Hospital Universitario La Paz.
Gastrointestinal Oncology
Investigations target malignant neoplasms of the digestive tract, including Colorectal Cancer, Gastric Adenocarcinoma, Pancreatic Ductal Adenocarcinoma and Esophageal Squamous Cell Carcinoma, with an emphasis on precision medicine and novel treatment combinations.
- Targeted therapies for KRAS‑mutated tumors
- Immunotherapy‑based combination regimens
- Neoadjuvant and adjuvant treatment pathways
- Biomarker‑driven patient selection
The program collaborates closely with oncology units at the affiliated research site.
Hepatobiliary & Cholestatic Disorders
Key interests include malignancies and inflammatory conditions of the biliary tree such as Cholangiocarcinoma, autoimmune liver diseases like Primary Biliary Cholangitis, and symptom‑focused entities such as Cholestatic Pruritus.
- FGFR‑targeted agents for cholangiocarcinoma
- Ursodeoxycholic acid alternatives
- Quality‑of‑life assessment tools for pruritus
- Liver transplant eligibility criteria
Research integrates hepatology expertise within the same Madrid centre.
Gastrointestinal Infectious Diseases
Efforts address recurrent and severe infections of the gastrointestinal tract, notably Clostridioides difficile infection and other enteric bacterial pathologies, aiming to improve therapeutic outcomes and reduce recurrence.
- Fecal microbiota transplantation efficacy
- Antibiotic stewardship protocols
- Prevention of recurrent infection
- Surveillance of antimicrobial resistance patterns
Clinical studies are coordinated through the gastroenterology department of the Hospital Universitario La Paz.
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