Lucero N. M.
- Country
- Spain
- Department
- Dermatology
Research Overview
- Evaluation of Baricitinib Pharmacokinetics, Efficacy, and Safety in Pediatric Patients with Moderate-to-Severe Atopic Dermatitis: A Phase 3 Randomized Controlled Trial
- Efficacy and Safety Evaluation of Ruxolitinib Cream in Pediatric Patients Aged 6 to <12 Years with Nonsegmental Vitiligo: A Phase 3 Randomized, Double-Blind Study
Data & Insights
Has run more than one trial at 10 of 79 partner sites.
Specializations
Dermatology & Immune‑Mediated Skin Disorders
Focus on inflammatory skin conditions, especially moderate‑to‑severe atopic dermatitis.
The program also addresses chronic plaque psoriasis.
- Biologic agents targeting IL‑4/IL‑13 pathways
- Topical corticosteroid combination therapies
- Anti‑IgE monoclonal antibodies
Emphasis on improving symptom control and quality of life in pediatric patients.
Pediatric Hematologic Malignancies
Clinical activity centers on childhood acute lymphoblastic leukemia.
Trials also include acute myeloid leukemia and related myelodysplastic syndromes.
- Targeted therapies for refractory disease
- Immunotherapy approaches for CD22‑positive leukemias
- Combination regimens with novel cytotoxic agents
Investigations prioritize molecularly defined subtypes and relapse prevention.
Solid Tumor Oncology in Children and Adolescents
Research investigates rare high‑grade glioma and diffuse intrinsic pontine glioma.
Efforts also target pediatric neuroblastoma.
Additional focus is on rhabdomyosarcoma and Ewing sarcoma subtypes.
- Precision medicine based on tumor genetics
- Adoptive cell therapies for solid tumors
- Novel anti‑angiogenic strategies
Aim to improve survival through targeted and immunotherapeutic approaches.
Respiratory and Allergic Diseases
Studies include moderate to severe asthma in children.
The program evaluates allergic rhinitis associated with pollen sensitization.
- Biologic inhibitors of type‑2 inflammation
- Combination inhaled therapies for acute exacerbations
- Allergen immunotherapy adjuncts
Objectives involve reducing exacerbations and enhancing airway control.
Genetic and Metabolic Rare Disorders
Clinical work addresses pediatric cystic fibrosis.
Investigations also cover pyruvate kinase deficiency.
- Gene‑editing and lentiviral vector strategies
- Long‑term safety monitoring of metabolic correction
- Quality‑of‑life assessments in rare disease cohorts
Long‑term safety and disease‑modifying outcomes are central goals.
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