Louis-Marie S.
- Country
- France
- Department
- Radiothérapie
Research Overview
Data & Insights
Has run more than one trial at 0 of 21 partner sites.
Specializations
Radiation Oncology and Therapeutic Radiology
Advances the use of ionizing radiation to eradicate malignant cells, integrating image‑guided techniques and adaptive planning.
- Intensity‑modulated radiotherapy for head and neck squamous cell carcinoma
- Proton beam therapy in glioma treatment
- Stereotactic radiosurgery for brain metastases
Emphasis is placed on maximizing tumor control while preserving surrounding healthy tissue.
Breast Cancer Therapeutics
Targets hormonal and HER2 pathways in early and advanced disease, incorporating novel endocrine agents and antibody‑drug conjugates.
- Hormone‑responsive ER‑positive/HER2‑negative breast cancer
- HER2‑low and HER2‑positive metastatic disease
- CDK4/6 inhibitor‑based combinations for advanced breast cancer
Research aims to improve survival and quality of life across disease stages.
Lung Cancer Immunotherapy and Targeted Therapy
Explores checkpoint inhibition and molecularly directed agents for both squamous and non‑small cell histologies.
- PD‑1/PD‑L1 blockade in non‑small cell lung cancer
- EGFR‑mutated disease treated with next‑generation inhibitors
- KRAS G12C‑specific therapies for advanced NSCLC
Efforts focus on extending durable responses and overcoming resistance mechanisms.
Genomics‑Driven Precision Medicine for Solid Tumors
Leverages molecular profiling to match patients with therapies targeting actionable alterations.
- FGFR3‑altered urothelial carcinoma
- ROS1‑rearranged lung cancer
- BRAF‑mutant melanoma and other solid tumors
Integration of biomarker data guides trial enrollment and therapeutic selection.
Neuro‑Oncology and Pediatric Brain Tumor Research
Focuses on high‑grade gliomas and diffuse midline gliomas, emphasizing radiotherapy optimization and molecular targeting.
- Diffuse intrinsic pontine glioma with H3K28M mutation
- Adult brainstem gliomas undergoing focal radiation
- MGMT‑unmethylated glioblastoma treated with combined modalities
Clinical strategies aim to improve outcomes while mitigating neurotoxicity.
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