Loes. M. L. J.
- Country
- The Netherlands
- Department
- Department of Internal Medicine
Research Overview
- Evaluation of GDC-6036 Monotherapy and Combination Therapy in Advanced or Metastatic Solid Tumors with KRAS G12C Mutation
- Phase III Trial of BI 764532 Plus Carboplatin and Etoposide Versus Carboplatin and Etoposide in Previously Untreated DLL3-Positive Advanced Extrapulmonary Neuroendocrine Carcinoma
- Phase II Study of LY4337713 in Patients with FAP‑Positive Solid Tumors (Ovarian, Breast, Pancreatic, Colorectal, Esophageal, Gastric, Cholangiocarcinoma)
Data & Insights
Has run more than one trial at 46 of 179 partner sites.
Specializations
Thoracic Oncology
Clinical research in non-small cell lung cancer and small cell lung cancer spans locally advanced, metastatic, and biomarker-defined disease, with particular attention to EGFR-driven, ALK-positive, KRAS G12C-positive, and PD-L1-selected populations.
- Non-Small Cell Lung Cancer
- Small Cell Lung Cancer
- EGFR-mutated disease
- Extensive-stage small-cell lung cancer
- Metastatic thoracic malignancies
Interest also extends to perioperative and adjuvant treatment strategies, brain metastases, and precision-matched therapy for advanced lung cancer.
Hematologic Malignancies
The investigator is involved in studies across aggressive and indolent blood cancers, including diffuse large B-cell lymphoma, Hodgkin lymphoma, chronic lymphocytic leukemia, multiple myeloma, and acute myeloid leukemia.
- Diffuse Large B-Cell Lymphoma
- Hodgkin lymphoma
- Chronic Lymphocytic Leukemia
- Multiple Myeloma
- Acute Myeloid Leukemia
Additional work includes CAR T-cell therapy, bispecific antibodies, and consolidation or maintenance approaches in relapsed or high-risk disease.
Solid Tumors and Precision Oncology
Research activity covers a broad spectrum of solid tumors, with recurring involvement in breast cancer, pancreatic cancer, colorectal cancer, urothelial carcinoma, melanoma, and endometrial cancer.
- Breast Cancer
- Pancreatic Cancer
- Colorectal Cancer
- Urothelial Carcinoma
- Melanoma
Therapeutic interests include immune checkpoint inhibition, antibody-drug conjugates, and biomarker-directed treatment in advanced and metastatic settings.
Cardiovascular and Thrombotic Disease
Clinical studies also address heart failure, acute coronary syndrome, stroke, atrial fibrillation, hypertension, and peripheral arterial disease, reflecting a strong cardiovascular focus within internal medicine.
- Heart Failure
- Acute Coronary Syndrome
- Stroke
- Atrial Fibrillation
- Hypertension
Research interests include prevention of ischemic events, management of bleeding risk, and cardiorenal protection in complex cardiovascular disease.
Autoimmune, Gastrointestinal, and Rare Disease Care
The investigator is engaged in trials in inflammatory bowel disease, Crohn's disease, ulcerative colitis, systemic lupus erythematosus, amyloidosis, and chronic kidney disease, alongside selected rare disorders.
- Inflammatory Bowel Disease
- Crohn's Disease
- Systemic Lupus Erythematosus
- Transthyretin Amyloidosis
- Chronic Kidney Disease
Other areas include transplant-related complications, corneal transplantation, and rare inherited or metabolic conditions requiring specialized therapeutic development.
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