Loes J.
- Country
- The Netherlands
- Department
- Medical oncology
Research Overview
- Evaluation of GDC-6036 Monotherapy and Combination Therapy in Advanced or Metastatic Solid Tumors with KRAS G12C Mutation
- Phase 2 Multicenter Study of Patritumab Deruxtecan in Patients with Locally Advanced or Metastatic Solid Tumors
- Randomized Controlled Trial of RYZ101 Versus Standard of Care in Advanced SSTR+ Gastroenteropancreatic Neuroendocrine Tumors Post-177Lu-SSA Therapy
Data & Insights
Has run more than one trial at 38 of 123 partner sites.
Specializations
Advanced Solid Tumor Oncology
Focuses on targeted and immunotherapeutic strategies for aggressive solid malignancies.
- non‑small cell lung cancer
- pancreatic ductal adenocarcinoma
- renal cell carcinoma
- hepatocellular carcinoma
- melanoma
Clinical activity is coordinated through two Maastricht academic hospitals: Academisch Ziekenhuis Maastricht and University Hospital Maastricht.
Hematologic Malignancies and Bone Marrow Disorders
Develops novel immuno‑oncology and kinase‑inhibitor approaches for blood‑derived cancers.
- acute myeloid leukemia
- diffuse large B‑cell lymphoma
- multiple myeloma
- chronic lymphocytic leukemia
- myelodysplastic syndrome
Research integrates translational insights from the department of medical oncology.
Cardiovascular and Metabolic Therapeutics
Explores therapies for heart failure, arterial disease, and metabolic dysregulation.
- heart failure with preserved ejection fraction
- acute coronary syndrome
- atrial fibrillation
- hypertension
- type 2 diabetes
Studies often involve multidisciplinary collaboration across cardiology and oncology units.
Transplant Immunology and Rare Genetic Conditions
Investigates immune modulation in organ transplantation and hereditary cardiomyopathies.
- dilated cardiomyopathy genetic carriers
- renal transplantation
- systemic lupus erythematosus
- transthyretin amyloidosis
- hereditary cardiomyopathy
Efforts are supported by the European network of rare disease research.
Pediatric and Developmental Disorders
Addresses therapeutic needs in childhood neurology and developmental disease.
- apnea of prematurity
- Menière's disease
- cerebral palsy
- neurodevelopmental disorders
- premature lung disease
Collaborations extend to neonatal and pediatric specialty centers.
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