Lissy D. R.
- Country
- The Netherlands
- Department
- Children Gastroenterology and Hepatology
Research Overview
- I6T-MC-AMBA - A Multicenter, Phase 3, Open-Label Study to Investigate the Efficacy, Pharmacokinetics, and Safety of Mirikizumab in Participants 2 Years to Less Than 18 Years of Age with Moderately to Severely Active Ulcerative Colitis
- Pharmacokinetic Evaluation of Infliximab in Pediatric Patients with Crohn's Disease: A Prospective Analysis
- Efficacy and Safety Evaluation of Darvadstrocel for Complex Perianal Fistulas in Pediatric Crohn's Disease: A Phase 3, Open-Label, Multicenter Study
Data & Insights
Has run more than one trial at 4 of 37 partner sites.
Specializations
Pediatric Gastroenterology and Intestinal Inflammation
Pediatric gastroenterology is a central area of interest, with clinical research activity spanning Crohn’s disease, ulcerative colitis, inflammatory bowel disease, and eosinophilic esophagitis. The portfolio also includes chronic pancreatitis and other gastrointestinal conditions affecting children and adolescents.
- Crohn’s disease
- Ulcerative colitis
- Inflammatory bowel disease
- Eosinophilic esophagitis
Research activity is linked to clinical care at Erasmus MC in Rotterdam and LUMC in Leiden.
Allergic and Immune-Mediated Disorders
Clinical trial involvement extends to atopic dermatitis, hidradenitis suppurativa, peanut allergy, and immune-mediated skin and inflammatory disorders, reflecting interest in conditions driven by dysregulated immune responses.
- Atopic dermatitis
- Hidradenitis suppurativa
- Peanut allergy
- Immune-mediated inflammatory disease
The therapeutic focus includes both chronic symptom control and disease-modifying approaches in immune-driven pediatric and adolescent conditions.
Hepatobiliary and Metabolic Liver Disease
Research interests include primary biliary cholangitis, primary sclerosing cholangitis, metabolic dysfunction-associated steatotic liver disease, and non-alcoholic steatohepatitis, with attention to pruritus and chronic liver-related complications.
- Primary biliary cholangitis
- Primary sclerosing cholangitis
- Metabolic dysfunction-associated steatotic liver disease
- Non-alcoholic steatohepatitis
These areas connect gastrointestinal practice with broader hepatology-focused therapeutic development.
Pancreatic and Gastrointestinal Oncology
The investigator is also involved in trials addressing pancreatic cancer, colorectal cancer, and other gastrointestinal malignancies, including resectable and metastatic disease settings.
- Pancreatic cancer
- Colorectal cancer
- Gastroesophageal cancer
- Advanced gastrointestinal malignancies
This work reflects engagement with evolving therapeutic strategies in digestive tract oncology.
Nutritional and Growth-Related Pediatric Conditions
Clinical research also covers short stature, obesity, and related pediatric metabolic concerns, alongside gastrointestinal conditions that affect growth, nutrition, and long-term development.
- Short stature
- Obesity
- Pediatric metabolic disorders
- Growth-related conditions
These topics align with the clinical management of children whose digestive or metabolic disease influences nutritional status and development.
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