Lionel A.
- Country
- France
- Department
- Hematologie Seniors
Research Overview
- Efficacy of Ziftomenib Combined with Standard of Care Therapy in Patients with Untreated NPM1-Mutated or KMT2A-Rearranged Acute Myeloid Leukemia
- Phase II Study of Imetelstat Sodium in High‑Risk MDS and AML Patients Refractory to Hypomethylating Agent Therapy
- Phase 3 Randomized Open‑Label Study of Elritercept Versus Epoetin Alfa for Anemia in ESA‑Naïve Adults with Lower‑Risk Myelodysplastic Syndromes Requiring RBC Transfusions
Data & Insights
Has run more than one trial at 129 of 286 partner sites.
Specializations
Hematologic malignancies
Clinical research activity is centered on acute myeloid leukemia, acute lymphoblastic leukemia, myelodysplastic syndromes, multiple myeloma, and lymphoma, with attention to both newly diagnosed and relapsed or refractory disease.
- Acute myeloid leukemia
- Acute lymphoblastic leukemia
- Myelodysplastic syndromes
- Multiple myeloma
- Lymphoma
Work in this area also includes stem cell transplantation, graft-versus-host disease, and other blood cancers managed through senior hematology practice.
Autoimmune and inflammatory diseases
The investigator is involved in trials addressing systemic lupus erythematosus, lupus nephritis, rheumatoid arthritis, Sjögren’s disease, and systemic sclerosis, reflecting a strong therapeutic focus on immune-mediated disorders.
- Systemic lupus erythematosus
- Lupus nephritis
- Rheumatoid arthritis
- Sjögren’s disease
- Systemic sclerosis
Additional interests include vasculitis, idiopathic inflammatory myopathies, psoriatic arthritis, and other chronic inflammatory conditions requiring targeted therapy.
Solid tumors and precision oncology
Research spans a broad range of solid tumors, including non-small cell lung cancer, breast cancer, colorectal cancer, hepatocellular carcinoma, and gastrointestinal cancers, with repeated involvement in advanced and metastatic settings.
- Non-small cell lung cancer
- Breast cancer
- Colorectal cancer
- Hepatocellular carcinoma
- Gastrointestinal cancers
The portfolio also includes urothelial carcinoma, melanoma, ovarian cancer, and biomarker-driven oncology with HER2, FGFR, KRAS, and BRCA alterations.
Cardiovascular, renal, and critical care medicine
Clinical interests extend to cardiovascular disease, heart failure, myocardial infarction, stroke, venous thromboembolism, and atrial fibrillation, alongside acute care conditions seen in intensive care settings.
- Cardiovascular disease
- Heart failure
- Myocardial infarction
- Stroke
- Venous thromboembolism
Associated research also covers acute kidney injury, chronic kidney disease, sepsis, and critical care interventions relevant to hospitalized adult patients.
Respiratory, infectious, and rare diseases
Further activity includes interstitial lung disease, idiopathic pulmonary fibrosis, pulmonary hypertension, asthma, and chronic obstructive pulmonary disease, as well as infectious disease research in HIV, hepatitis B, and hepatitis C.
- Interstitial lung disease
- Idiopathic pulmonary fibrosis
- Pulmonary hypertension
- HIV
- Hepatitis B
The portfolio also includes rare diseases such as amyloidosis, myasthenia gravis, and transthyretin amyloidosis, broadening the therapeutic scope beyond common hospital-based disorders.
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