Libor C.
- Country
- Czechia
- Department
- Interni hematologicka a onkologicka klinika FN Brno
Research Overview
- Long-term Safety and Efficacy Evaluation of Danicopan as an Add-on to Complement Component 5 Inhibitors in Paroxysmal Nocturnal Hemoglobinuria Patients
- Evaluation of Long-Term Safety and Tolerability of Iptacopan in Patients with Paroxysmal Nocturnal Hemoglobinuria Post-Phase II/III Studies
- Phase 3 Randomized Controlled Trial of Pacritinib Versus Physician's Choice in Myelofibrosis Patients with Severe Thrombocytopenia
Data & Insights
Has run more than one trial at 42 of 126 partner sites.
Specializations
Hematologic malignancies
Clinical activity is strongly centered on acute myeloid leukemia, acute lymphoblastic leukemia, chronic lymphocytic leukemia, multiple myeloma, myelodysplastic syndromes, and myelofibrosis, with additional involvement in Hodgkin lymphoma, diffuse large B-cell lymphoma, mantle cell lymphoma, and follicular lymphoma.
- Acute myeloid leukemia
- Multiple myeloma
- Chronic lymphocytic leukemia
- Lymphoma
The trial portfolio also includes plasma cell disorders, relapsed or refractory disease, and post-transplant maintenance strategies within malignant hematology.
Cardiovascular medicine
Research interests extend to acute myocardial infarction, heart failure, atherosclerotic cardiovascular disease, atrial fibrillation, and hypercholesterolemia, reflecting sustained engagement in both acute and chronic cardiovascular care.
- Acute myocardial infarction
- Heart failure
- Atherosclerotic cardiovascular disease
- Thrombotic risk
Additional work includes anticoagulation reversal, major adverse cardiovascular events, and cardiometabolic risk in high-risk adult populations.
Autoimmune and inflammatory disorders
The investigator is involved in studies of myasthenia gravis, multiple sclerosis, ulcerative colitis, Crohn's disease, psoriatic arthritis, juvenile idiopathic arthritis, and atopic dermatitis.
- Myasthenia gravis
- Multiple sclerosis
- Inflammatory bowel disease
- Atopic dermatitis
Therapeutic interest also covers immune thrombocytopenia, autoimmune hemolytic anemia, vasculitis, and other immune-mediated conditions.
Solid tumors and pediatric oncology
Clinical research includes breast cancer, ovarian cancer, endometrial cancer, lung cancer, renal cell carcinoma, prostate cancer, and pancreatic cancer, alongside pediatric malignancies such as medulloblastoma, neuroblastoma, high-risk glioma, and rhabdomyosarcoma.
- Breast cancer
- Ovarian cancer
- Lung cancer
- Pediatric solid tumors
This area also includes metastatic disease, rare cancers, and tumor-specific targeted therapy across adult and pediatric settings.
Specialized rare diseases and supportive care
Further involvement spans hemophilia, amyloidosis, paroxysmal nocturnal hemoglobinuria, kidney disease, hepatitis D, cystic fibrosis, and sleep apnea, reflecting a broad interest in uncommon and complex disorders.
- Hemophilia
- Amyloidosis
- Paroxysmal nocturnal hemoglobinuria
- Rare inflammatory and genetic diseases
Additional therapeutic areas include ophthalmic disease, pulmonary disorders, gastrointestinal inflammation, and supportive care for patients with chronic illness.
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