Leonor C. G.
- Country
- Portugal
- Department
- #6351:Neurologia
Research Overview
- A DOUBLE-BLIND, RANDOMIZED, PLACEBO CONTROLLED TRIAL TO ASSESS SAFETY AND EFFICACY OF SLS-005 (TREHALOSE INJECTION, 90.5 MG/ML FOR INTRAVENOUS INFUSION) FOR THE TREATMENT OF ADULTS WITH SPINOCEREBELLAR ATAXIA
- Randomized, Double‑Blind, Placebo‑Controlled Phase 3 Trial of Oral Votoplam in Adults with Huntington’s Disease Assessing cUHDRS Progression
- Phase 1b/2a First‑in‑Human Randomized, Double‑Blind, Placebo‑Controlled, Multiple Ascending Intrathecal Dose Study of S233107 in Patients with Spinocerebellar Ataxia Type 3
Data & Insights
Has run more than one trial at 47 of 150 partner sites.
Specializations
Autoimmune & Inflammatory Disorders
The investigator studies systemic lupus erythematosus and cutaneous variants alongside related rheumatologic conditions.
- Cutaneous Lupus Erythematosus
- Chronic idiopathic urticaria
- Atopic dermatitis
- Psoriatic arthritis
- Primary biliary cholangitis
Therapeutic focus includes biologic modulation of immune pathways.
Neurodegenerative & Neurological Diseases
Research emphasizes Alzheimer’s disease and frontotemporal dementia alongside seizure disorders.
- Alzheimer’s disease
- Frontotemporal dementia
- Multiple sclerosis
- Dravet syndrome
- Focal onset seizures
Efforts target disease‑modifying agents and neuroprotective strategies.
Oncology & Hematology
Key interests involve acute lymphoblastic leukemia and solid tumor subtypes.
- Acute lymphoblastic leukemia
- Acute myeloid leukemia
- Non‑small cell lung cancer
- Melanoma
- Multiple myeloma
Investigations address targeted therapies and immuno‑oncology approaches.
Cardiovascular & Metabolic Diseases
Focus includes atherosclerotic cardiovascular disease and related metabolic risk factors.
- Atherosclerotic cardiovascular disease
- Atrial fibrillation
- Heart failure
- Type 2 diabetes
- Hypertriglyceridemia
Therapeutic work aims at reducing major adverse cardiovascular events.
Pulmonary & Renal Disorders
Clinical work covers chronic obstructive pulmonary disease and kidney disease manifestations.
- Chronic obstructive pulmonary disease
- Idiopathic pulmonary fibrosis
- Pulmonary arterial hypertension
- Chronic kidney disease
- Nephrotic syndrome
Research evaluates disease progression and organ‑protective interventions.
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