Thalia H.
- Country
- The Netherlands
- Department
- Kindergeneeskunde
Research Overview
- Sotorasib and Combination Therapy Versus Standard Chemotherapy in Treatment-Naïve Patients with KRAS p.G12C-Mutated Metastatic Colorectal Cancer
- Adjuvant Pembrolizumab Versus Capecitabine or Olaparib in Patients with Early-Stage Triple-Negative Breast Cancer with Residual Disease Following Neoadjuvant Therapy
- An Observational Study of Methotrexate Pharmacokinetics and Pharmacodynamics in Paediatric and Adolescent Patients with Crohn’s Disease
Data & Insights
Has run more than one trial at 77 of 258 partner sites.
Specializations
Cardiovascular Medicine
The investigator concentrates on atherosclerotic cardiovascular disease, acute coronary syndrome, heart failure, peripheral arterial disease and atrial fibrillation.
- Primary prevention of ASCVD
- Management of myocardial infarction
- Therapeutic strategies for heart failure with preserved ejection fraction
- Antithrombotic approaches in peripheral arterial disease
- Blood pressure and lipid modulation
Research integrates inflammatory biomarkers and novel lipid‑lowering agents.
Oncology
Active involvement in solid tumour and hematologic malignancies, including breast cancer, lung cancer, colorectal cancer, pancreatic cancer, melanoma and ovarian cancer.
- Targeted therapy in HER2‑positive breast cancer
- Immunotherapy for non‑small cell lung cancer
- Neoadjuvant strategies for pancreatic adenocarcinoma
- Adjuvant treatment in high‑risk ovarian cancer
- Combination regimens for metastatic melanoma
Emphasis on molecular profiling to guide precision medicine.
Hematology & Bone Marrow Disorders
Research spans acute myeloid leukemia, myelodysplastic syndromes, chronic lymphocytic leukemia, mantle cell lymphoma and polycythemia vera.
- Venetoclax‑based regimens in AML
- Azacitidine combinations for high‑risk MDS
- BTK inhibition in mantle cell lymphoma
- JAK2‑targeted therapy for polycythemia vera
- MRD‑driven strategies in CLL
Focus on integrating genomic risk stratification with therapeutic choice.
Immunology & Autoimmune Diseases
Investigations cover rheumatoid arthritis, psoriatic arthritis, axial spondyloarthritis, inflammatory bowel disease, multiple sclerosis and Sjögren’s syndrome.
- JAK inhibition in psoriatic arthritis
- IL‑6 blockade for systemic inflammation
- Biologic agents in axial spondyloarthritis
- Gut‑targeted therapies for IBD
- Neuro‑immune modulation in multiple sclerosis
Studies often assess patient‑reported outcomes and functional status.
Critical Care & Organ Protection
Engagement in acute kidney injury, sepsis, acute respiratory distress syndrome and organ‑failure prevention in intensive care settings.
- Renal protective strategies in AKI
- Anti‑inflammatory omega‑3 fatty acids in severe pancreatitis
- Ventilatory management in ARDS
- Sepsis‑induced coagulopathy mitigation
- Cardiogenic shock hemodynamic optimization
Trials prioritize early intervention and biomarker‑guided therapy.
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