Leonidas A.
- Country
- Germany
- Department
- Abteilung Medizinische Onkologie, Nationales Centrum für Tumorerkrankungen (NCT)
Research Overview
- Phase III Trial of BI 764532 Plus Carboplatin and Etoposide Versus Carboplatin and Etoposide in Previously Untreated DLL3-Positive Advanced Extrapulmonary Neuroendocrine Carcinoma
- Phase 3 Trial of Octreotide Subcutaneous Depot vs. Octreotide LAR or Lanreotide ATG in Unresectable/Metastatic GEP-NET Patients
- Evaluation of Ramucirumab and Dacarbazine Efficacy in Progressive Well-Differentiated Metastatic Pancreatic Neuroendocrine Tumors
Data & Insights
Has run more than one trial at 43 of 131 partner sites.
Specializations
Breast and Gastrointestinal Oncology
Leonidas Apostolidis is involved in breast cancer research spanning hormone receptor-positive, HER2-negative, HER2-positive, and triple-negative breast cancer, with attention to both early and advanced disease. His oncology portfolio also includes gastric cancer, gastroesophageal junction adenocarcinoma, esophageal adenocarcinoma, colorectal cancer, and biliary tract cancer.
- Advanced and early breast cancer
- Gastric and gastroesophageal junction adenocarcinoma
- Colorectal cancer
- Biliary tract cancer
- Neoadjuvant and post-neoadjuvant treatment strategies
His work reflects a strong therapeutic focus on biomarker-linked oncology and treatment optimization across solid tumors with high unmet need.
Genitourinary and Renal Malignancies
His clinical research activity includes renal cell carcinoma, urothelial carcinoma, prostate cancer, and bladder cancer, covering both metastatic and locally advanced settings. He is also engaged in studies of gastrointestinal stromal tumor and other solid tumors with actionable molecular features.
- Renal cell carcinoma
- Urothelial carcinoma
- Prostate cancer
- Bladder cancer
- Molecularly selected solid tumors
These interests align with therapeutic development in advanced genitourinary oncology and targeted treatment selection.
Hematologic Malignancies and Cellular Therapies
Leonidas Apostolidis is active in acute myeloid leukemia, acute lymphoblastic leukemia, chronic myeloid leukemia, multiple myeloma, and lymphoma, including diffuse large B-cell lymphoma, mantle cell lymphoma, and follicular lymphoma. His portfolio also includes myelodysplastic syndromes, myeloproliferative neoplasms, and cellular immunotherapy.
- Acute and chronic leukemias
- Multiple myeloma
- Non-Hodgkin lymphoma
- Myelodysplastic and myeloproliferative disorders
- Cell and transplant-based therapies
His therapeutic interests extend to post-transplant management and advanced hematologic treatment approaches.
Cardiovascular and Amyloid Disorders
His research landscape includes cardiovascular disease, heart failure, acute myocardial infarction, atherosclerotic cardiovascular disease, and atrial fibrillation. He is also involved in studies of transthyretin amyloidosis, AL amyloidosis, and cardiomyopathy, including hypertrophic cardiomyopathy and dilated cardiomyopathy.
- Heart failure and myocardial infarction
- Atherosclerotic cardiovascular disease
- Transthyretin and AL amyloidosis
- Cardiomyopathy
- Stroke and thrombotic risk prevention
His therapeutic focus includes disease-modifying approaches for infiltrative cardiac disease and prevention of major cardiovascular events.
Immune-Mediated, Renal, and Metabolic Diseases
He is involved in research on ulcerative colitis, Crohn's disease, systemic lupus erythematosus, lupus nephritis, rheumatoid arthritis, and psoriasis. Additional interests include chronic kidney disease, IgA nephropathy, focal segmental glomerulosclerosis, atopic dermatitis, type 1 diabetes mellitus, and prediabetes.
- Inflammatory bowel disease
- Autoimmune rheumatic and dermatologic disease
- Immune-mediated kidney disease
- Type 1 diabetes and prediabetes
- Renal and proteinuric disorders
His therapeutic scope also covers chronic inflammatory conditions and organ-specific immune dysregulation.
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