Leire Perez L.
- Country
- Spain
- Department
- Infectious Diseases
Research Overview
- A Phase 3, Randomized, Active-Controlled, Double-Blind Clinical Study to Evaluate the Antiretroviral Activity, Safety, and Tolerability of Doravirine/Islatravir (DOR/ISL 100 mg/0.25 mg) Once-Daily in HIV-1 Infected Treatment-Naïve Participants
- Evaluation of Safety, Pharmacokinetics, and Antiviral Activity of IMC-M113V in HLA-A*2:01 Positive Patients with Virologically Suppressed Chronic HIV Infection
Data & Insights
Has run more than one trial at 3 of 24 partner sites.
Specializations
Infectious Diseases & Immunology
The investigator concentrates on infections caused by Mycobacterium avium complex, viral pathogens such as COVID-19, and opportunistic fungal organisms in immunocompromised hosts.
- Mycobacterial lung infection
- Severe acute respiratory syndrome
- Clostridioides difficile
- Invasive candidiasis
- CMV infection in transplant recipients
Research emphasizes pathogen‑specific therapeutic strategies and host immune modulation.
Oncology & Hematologic Malignancies
Focused on a broad spectrum of solid tumours and blood cancers, including non‑small cell lung cancer, breast carcinoma, and hematologic entities such as acute myeloid leukemia.
- NSCLC with KRAS G12C mutation
- HER2‑positive breast cancer
- Multiple myeloma
- Diffuse large B‑cell lymphoma
- Metastatic melanoma
Efforts target novel targeted agents, immunotherapies, and combination regimens.
Autoimmune & Inflammatory Disorders
The investigator’s work includes systemic autoimmune conditions such as systemic lupus erythematosus, rheumatoid arthritis, and skin inflammation like atopic dermatitis.
- Lupus nephritis
- Active idiopathic inflammatory myopathies
- Moderate‑to‑severe atopic dermatitis
- Autoimmune cytopenias
- Psoriatic arthritis
Research aims to modulate dysregulated immune pathways and improve disease control.
Cardiovascular & Metabolic Medicine
Key interests involve cardiovascular risk reduction and metabolic disease management, including acute myocardial infarction, heart failure, and type 2 diabetes mellitus.
- Acute coronary syndrome
- Heart failure with reduced ejection fraction
- Atherosclerotic cardiovascular disease
- Obesity‑related metabolic dysfunction
- Non‑alcoholic steatohepatitis
Studies explore anti‑inflammatory and metabolic‑targeted therapies to mitigate organ damage.
Transplantation & Graft‑Versus‑Host Complications
Specialized in complications arising from hematopoietic and solid‑organ transplantation, such as acute graft‑versus‑host disease and chronic immune‑mediated sequelae.
- Acute GVHD
- Chronic GVHD
- Post‑transplant infections
- Thrombotic microangiopathy after transplant
- Immune reconstitution monitoring
Efforts focus on prophylaxis, early detection, and therapeutic mitigation of transplant‑related morbidity.
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