Dierickx L.
- Country
- France
- Department
- 1403: Nuclear medicine and metabolic irradiation
Research Overview
- Evaluation of Lutetium (177Lu) Edotreotide Versus Standard Care in Aggressive Grade 2/3 SSTR+ Gastroenteropancreatic Neuroendocrine Tumors
- Phase III Study on the Efficacy and Safety of 177Lu-Edotreotide PRRT Versus Everolimus in Inoperable, Progressive SSTR+ GEP-NET Patients
- Evaluation of Retreatment Protocols with Lutetium (177Lu) Oxodotreotide in Patients with Progressive Intestinal Well-Differentiated Neuroendocrine Tumors
Data & Insights
Has run more than one trial at 25 of 72 partner sites.
Specializations
Oncology and Solid Tumors
Clinical activity is centered on advanced solid tumors, with strong involvement in breast cancer, non-small cell lung cancer, gastrointestinal malignancies, and sarcomas. The investigator also works across urothelial carcinoma, ovarian cancer, head and neck squamous cell carcinoma, and hepatocellular carcinoma, reflecting a broad therapeutic focus in complex metastatic disease.
- Metastatic breast cancer
- Non-small cell lung cancer
- Gastroesophageal and pancreatic cancers
- Soft tissue sarcoma
- Urothelial and ovarian malignancies
Research interest extends to biomarker-defined cancers and treatment-resistant disease, including HER2-positive, HR-positive, and KRAS- or EGFR-altered tumors.
Hematology and Hematologic Malignancies
The investigator is involved in studies of acute leukemias, myelodysplastic syndromes, multiple myeloma, and lymphomas. This includes work in acute myeloid leukemia, acute lymphoblastic leukemia, chronic lymphocytic leukemia, and aggressive or relapsed lymphoid disorders.
- Acute myeloid leukemia
- Acute lymphoblastic leukemia
- Myelodysplastic syndromes
- Multiple myeloma
- Diffuse large B-cell lymphoma
Additional activity includes stem cell transplantation-related settings and high-risk or relapsed hematologic disease.
Immune-Mediated and Inflammatory Diseases
Research also covers autoimmune diseases and inflammatory disorders, with attention to systemic lupus erythematosus, lupus nephritis, rheumatoid arthritis, psoriatic arthritis, and Crohn’s disease. The investigator is additionally involved in vasculitis, sarcoidosis, and mucous membrane pemphigoid.
- Systemic lupus erythematosus
- Rheumatoid arthritis
- Crohn’s disease
- Vasculitis
- Psoriatic and pemphigoid disorders
Therapeutic interests include refractory immune disease, organ-specific inflammation, and immune dysregulation affecting the skin, kidneys, lungs, and joints.
Cardiovascular, Renal, and Metabolic Medicine
The investigator contributes to trials in cardiovascular disease, acute myocardial infarction, atrial fibrillation, heart failure, and stroke. Renal interests include chronic kidney disease, kidney transplant rejection, proteinuric kidney disease, and acute kidney injury, alongside metabolic conditions such as obesity and type 2 diabetes.
- Acute and chronic cardiovascular disease
- Kidney disease and transplant complications
- Proteinuric renal disorders
- Diabetes and obesity
- Thromboembolic and cerebrovascular disease
Work in this area includes conditions linked to vascular risk, renal protection, and post-acute cardiovascular recovery.
Pulmonary, Neurologic, and Rare Disease Therapeutics
Additional clinical research spans pulmonary fibrosis, asthma, bronchiectasis, pulmonary hypertension, and chronic pulmonary aspergillosis. The investigator is also involved in neurologic disorders such as Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, and epilepsy, as well as selected rare diseases including amyloidosis and mastocytosis.
- Interstitial and fibrotic lung disease
- Neurodegenerative disorders
- Multiple sclerosis and epilepsy
- Amyloidosis and mastocytosis
- Rare pulmonary infections and airway disease
Therapeutic interest also includes conditions with limited treatment options, particularly where targeted or immune-based approaches are being explored.
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