Laurent P. B.
- Country
- France
- Department
- Clinical Investigation Unit
Research Overview
- A Phase 2b, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety and Efficacy of 3 Active Dose Regimens of MORF-057 in Adults with Moderately to Severely Active Ulcerative Colitis (EMERALD-2)
- Efficacy and Safety of Upadacitinib in Maintenance and Long-Term Extension for Crohn's Disease Post-Induction Responders
- Long-Term Efficacy, Safety, and Tolerability of Repeated Upadacitinib Administration in Crohn's Disease: A Phase 2 Multicenter Open-Label Extension Study
Data & Insights
Has run more than one trial at 26 of 200 partner sites.
Specializations
Inflammatory Bowel Disease
This investigator is closely involved in clinical research on inflammatory bowel disease, with a strong focus on Crohn's disease and ulcerative colitis. The therapeutic landscape includes disease control, symptom relief, and improvement of intestinal inflammation in chronic relapsing bowel disorders.
- Moderately to severely active Crohn’s disease
- Moderately to severely active ulcerative colitis
- Fistulizing perianal Crohn’s disease
- Immune-mediated bowel inflammation
Research activity in this area also extends to endoscopic response, clinical remission, and treatment strategies for difficult-to-control intestinal inflammation.
Hepatology and Chronic Liver Disease
Clinical interest includes hepatology and advanced chronic liver disease, particularly hepatocellular carcinoma, metabolic dysfunction-associated steatohepatitis, and non-alcoholic steatohepatitis. The therapeutic focus spans liver inflammation, fibrosis, cirrhosis, and malignancy arising in chronic liver disease.
- Unresectable hepatocellular carcinoma
- Compensated cirrhosis due to MASH/NASH
- Fibrotic liver disease
- Biliary and hepatic oncology
Work in this domain reflects involvement in medical innovation for both fibrosis regression and treatment development in liver cancer.
Haematology and Blood Cancers
The investigator is active in haematology, with research spanning acute myeloid leukemia, acute lymphoblastic leukemia, myelodysplastic syndrome, and lymphoma. This includes both malignant blood disorders and related transplant-associated complications.
- Acute myeloid leukemia
- Acute lymphoblastic leukemia
- Myelodysplastic syndrome
- B-cell lymphoma and related subtypes
Research also covers multiple myeloma, chronic lymphocytic leukemia, and stem cell transplantation, indicating broad engagement in hematologic malignancy care.
Immune-Mediated and Autoimmune Disorders
Another important area is autoimmune disease and immune-mediated inflammation, including systemic lupus erythematosus, vasculitis, rheumatoid arthritis, and systemic sclerosis. The therapeutic interest is centered on controlling refractory inflammatory disease and organ-specific immune injury.
- Systemic lupus erythematosus
- ANCA-associated vasculitis
- Rheumatoid arthritis
- Systemic sclerosis
This research area also includes giant cell arteritis, idiopathic inflammatory myopathies, and immune thrombocytopenia.
Cardiovascular, Critical Care, and Thrombotic Disease
Clinical research involvement also extends to cardiovascular disease, atrial fibrillation, heart failure, stroke, and cardiogenic shock. The therapeutic landscape includes vascular prevention, rhythm-related complications, and acute care conditions requiring intensive management.
- Atrial fibrillation and stroke prevention
- Heart failure
- Acute ischemic stroke
- Septic shock and post-resuscitation care
Research activity in this domain also covers thromboembolic disease, acute coronary syndrome, and critical care medicine.
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