Laurent B.
- Country
- France
- Department
- Oncology-radiotherapy
Research Overview
Data & Insights
Has run more than one trial at 0 of 107 partner sites.
Specializations
Radiotherapy for Solid Tumors
Focused on integrating radiotherapy with systemic treatments for thoracic, renal, prostate and head‑and‑neck malignancies.
- Concurrent chemoradiation in locally advanced lung cancer
- Adjuvant pelvic radiotherapy for high‑risk prostate cancer
- Radiation‑enhanced immunotherapy in renal cell carcinoma
- Definitive radiotherapy for head‑and‑neck squamous cell carcinoma
Emphasis on dose optimization and multidisciplinary coordination to improve local control.
Immuno‑Oncology and Targeted Combinations
Investigation of checkpoint inhibition and novel agents such as anti‑TIGIT in combination with chemotherapy or radiotherapy.
- PD‑1 blockade in first‑line non‑small cell lung cancer
- Anti‑TIGIT plus docetaxel in advanced lung carcinoma
- Dual checkpoint inhibition with CTLA‑4 and PD‑L1 in hepatocellular carcinoma
- Targeted KRAS G12C inhibition in colorectal adenocarcinoma
Goal is to enhance anti‑tumor immunity and overcome resistance mechanisms.
Neuro‑Oncology and Neurological Disorders
Exploration of therapeutic strategies for brain‑related malignancies and central nervous system diseases.
- Adjunctive gabapentin for acute lumbosacral radiculalgia
- Novel anti‑seizure agents in focal epilepsy
- Caffeine modulation of cognitive decline in Alzheimer disease
- Management of brain metastases in breast cancer patients
Integrates pharmacologic and supportive approaches to preserve neurological function.
Critical Care and Infectious Disease Management
Clinical evaluation of antimicrobial and supportive therapies for severe infections and sepsis.
- Carbapenem‑sparing regimens for ESBL‑producing Enterobacteriaceae
- Oral rifabutin versus rifampicin in prosthetic joint infection
- High‑dose vitamin C in post‑cardiac arrest shock
- Dobutamine infusion for septic cardiomyopathy
Targets reduction of mortality and organ dysfunction in intensive care settings.
Cardiovascular and Renal Complications in Oncology
Assessment of anticoagulation and renal protection strategies in patients with co‑morbid conditions.
- Apixaban versus warfarin in peritoneal dialysis patients with atrial fibrillation
- Vitamin B3 supplementation to prevent kidney injury during septic shock
- Management of non‑valvular atrial fibrillation in end‑stage renal disease
- Renal safety of combined immunotherapy and radiotherapy
Focuses on balancing oncologic efficacy with cardiovascular and renal health.
Related Investigators
Researchers in similar fields or departments
Want to know more about this investigator?
We can share extended profile information and contact details.
Is something out of date?
Tell us what needs correcting and we'll update this profile.