Laurence S.
- Country
- France
- Department
- Hématologie Clinique
Research Overview
- Phase 3 Study of Idarubicin, Daunorubicin, Cytarabine, and Mycophenolic Acid in Acute Myeloid Leukemia Patients Aged 18-60
- Phase 3 Randomized, Double-blind, Placebo-controlled Study of Tamibarotene and Azacitidine in RARA-positive Higher-risk Myelodysplastic Syndrome
- Phase III Randomized Double-Blind Trial of Polatuzumab Vedotin, Rituximab, and CHP vs. Rituximab and CHOP in Untreated Diffuse Large B-Cell Lymphoma
Data & Insights
Has run more than one trial at 84 of 194 partner sites.
Specializations
Hematologic malignancies
Clinical research activity centers on acute leukemias, chronic lymphocytic leukemia, myelodysplastic syndromes, and myeloproliferative neoplasms, with additional involvement in aggressive lymphoid cancers and plasma cell disorders.
- Acute myeloid leukemia
- Acute lymphoblastic leukemia
- Diffuse large B-cell lymphoma
- Multiple myeloma
- Chronic myeloid leukemia
The therapeutic focus includes targeted therapy, immunotherapy, and stem cell transplantation in blood cancers managed at Centre Hospitalier De Perpignan.
Myeloid and lymphoid treatment innovation
Investigator involvement extends across relapsed or refractory lymphoma, high-risk myeloma, and RARA-positive myelodysplastic syndrome, reflecting a strong interest in therapy optimization for difficult-to-treat hematologic disease.
- Peripheral T-cell lymphoma
- Follicular lymphoma
- Waldenström macroglobulinemia
- Myelodysplastic syndrome
- Myeloma maintenance strategies
Research interests also include minimal residual disease assessment and post-transplant maintenance approaches in hematologic oncology.
Autoimmune and inflammatory diseases
Clinical work also covers systemic vasculitis, giant cell arteritis, eosinophilic granulomatosis with polyangiitis, and granulomatosis with polyangiitis, with attention to remission induction and maintenance.
- Giant cell arteritis
- Granulomatosis with polyangiitis
- Microscopic polyangiitis
- Eosinophilic granulomatosis with polyangiitis
- Behçet’s disease uveitis
Therapeutic interests include biologic therapy, glucocorticoid-sparing strategies, and immune-mediated eye disease.
Solid tumors and gastrointestinal oncology
Research involvement includes colorectal cancer, pancreatic adenocarcinoma, esophageal cancer, cholangiocarcinoma, and hepatocellular carcinoma, with a focus on advanced and metastatic disease.
- Metastatic colorectal cancer
- Pancreatic adenocarcinoma
- Gastro-oesophageal junction adenocarcinoma
- Hepatocellular carcinoma
- Ampullary adenocarcinoma
Key therapeutic interests include chemotherapy, immunotherapy, and precision oncology for gastrointestinal malignancies.
Infectious, vascular, and cardio-renal conditions
Additional trial activity spans staphylococcal bacteremia, prosthetic joint infection, pulmonary mycobacterial infection, acute ischemic stroke, and cardio-renal risk after intensive care.
- Staphylococcus aureus bacteremia
- Mycobacterium xenopi pulmonary infection
- Acute ischemic stroke due to basilar artery occlusion
- Chronic kidney disease with uncontrolled hypertension
- Cardio-renal protection after ICU discharge
These interests connect anti-infective therapy, thrombosis prevention, and renal-cardiovascular protection within clinical innovation.
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