Oddeke V. R.
- Country
- The Netherlands
- Department
- Surgery
Research Overview
- A Phase III double-blind placebo-controlled Randomised Trial of Aspirin on Recurrence and Survival in Colon Cancer Patients
- Evaluation of Hepatic Arterial Infusion of Floxuridine with Systemic Therapy in Unresectable Colorectal Liver Metastases: A Randomized Controlled Trial
- Phase III Multicenter Randomized Trial of Dose-Reduced Chemotherapy with Fluorouracil, Folinic Acid, Capecitabine, and Oxaliplatin in Metastatic Colorectal Cancer
Data & Insights
Has run more than one trial at 50 of 73 partner sites.
Specializations
Colorectal surgery and liver metastases
Clinical research in colorectal cancer focuses on postoperative risk reduction, organ-preserving strategies, and treatment intensification for colorectal liver metastases, including patients with resectable and unresectable disease.
- Colon cancer
- Metastatic colorectal cancer
- Hepatic arterial infusion pump chemotherapy
- Rectal cancer
Work also includes surgical decision-making after local excision and approaches aimed at improving progression-free survival in advanced gastrointestinal malignancy.
Rectal preservation and organ-sparing oncology
The investigator is involved in research on early rectal cancer and strategies that support rectal preservation, including surveillance-based management and combined local and adjuvant treatment pathways.
- Early-stage rectal cancer
- Completion surgery
- Chemoradiotherapy
- Watchful waiting
This area also covers outcomes in resected colon carcinoma and resectable colorectal rectal metastases without extrahepatic disease.
Breast cancer and vulvar neoplasia
Research activity includes treatment optimization for triple negative breast cancer and hormone receptor-positive metastatic breast cancer, alongside prevention of recurrence in vulvar high-grade squamous intraepithelial lesion.
- Triple negative breast cancer
- HR+/HER2- metastatic breast cancer
- Adjuvant systemic therapy
- Vulvar HSIL
These studies reflect an interest in adjuvant treatment strategies, recurrence prevention, and disease control in gynecologic and breast malignancies.
Inflammatory and infectious disease
The clinical portfolio also extends to rheumatoid arthritis, psoriatic arthritis, sepsis, and respiratory tract infection, with attention to treatment tailoring and acute care outcomes.
- Rheumatoid arthritis
- Psoriatic arthritis
- Sepsis
- Acute respiratory tract infection
Additional interest is shown in disease activity control, antibiotic-related interventions, and JAK inhibitor-based management in chronic inflammatory disease.
General surgical infection and abdominal complications
Within surgical care, the investigator studies complications of appendicitis and perianal abscess, with emphasis on preventing postoperative infectious sequelae and fistula formation.
- Complicated appendicitis
- Perianal abscess
- Intra-abdominal abscess
- Perianal fistula
This area connects operative management with infection prevention in common colorectal and emergency surgical conditions.
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