Lachezar L.
- Country
- Bulgaria
- Department
- Clinic for Internal Diseases, Department for Endocrinology and Internal Diseases
Research Overview
- Efficacy and safety of zenagamtide versus semaglutide in participants with overweight or obesity and type 2 diabetes
- Phase III Randomized Open‑Label Trial Evaluating Elecoglipron Versus Oral Semaglutide for Glycemic Control in Adults with Type 2 Diabetes Mellitus
- Evaluation of Maridebart Cafraglutide Efficacy and Safety in Adults with Type 2 Diabetes Mellitus and Obesity or Overweight: A Phase 3 Randomized, Double-blind Study
Data & Insights
Has run more than one trial at 39 of 283 partner sites.
Specializations
Metabolic and Liver Diseases
Clinical research activity includes non-alcoholic steatohepatitis, metabolic dysfunction-associated steatotic liver disease, metabolic dysfunction-associated steatohepatitis, primary biliary cholangitis, alcohol-related liver disease, and hepatic encephalopathy, with a strong therapeutic interest in chronic liver inflammation, fibrosis, and cirrhosis.
- NASH and liver fibrosis
- MASH and compensated cirrhosis
- Primary biliary cholangitis
- Hepatic encephalopathy
Work in this area also extends to severe hypertriglyceridemia and chronic weight management, reflecting an interest in metabolic risk reduction.
Cardiovascular and Thrombotic Disorders
The investigator is involved in studies of atrial fibrillation, ischemic stroke, myocardial infarction, high cardiovascular risk, cardiovascular disease, and heart failure, with attention to prevention of major adverse cardiovascular events.
- Atrial fibrillation
- Acute ischemic stroke and high-risk TIA
- High cardiovascular risk
- Non-ischemic cardiomyopathy
Additional involvement includes hypertension and broader vascular prevention strategies in patients with established or emerging cardiovascular disease.
Inflammatory and Autoimmune Diseases
Research interests cover psoriatic arthritis, systemic lupus erythematosus, ulcerative colitis, Crohn’s disease, hidradenitis suppurativa, and immune-mediated inflammatory disease, indicating a broad focus on chronic immune dysregulation.
- Psoriatic arthritis
- Systemic lupus erythematosus
- Ulcerative colitis
- Crohn’s disease
This therapeutic area also includes immune thrombocytopenia and other immune system diseases requiring long-term disease control.
Neurology and Neuroinflammation
Clinical trial involvement includes multiple sclerosis across relapsing and progressive forms, Parkinson’s disease, serum neurofilament-related neuroinflammatory assessment, and broader nervous system diseases.
- Multiple sclerosis
- Primary progressive multiple sclerosis
- Secondary progressive multiple sclerosis
- Parkinson’s disease
Research also includes acute ischemic stroke prevention and other neurological conditions linked to inflammatory and vascular mechanisms.
Hematology, Oncology, and Infectious Disease
The investigator’s portfolio includes multiple myeloma, chronic lymphocytic leukemia, follicular lymphoma, marginal zone lymphoma, myelofibrosis, and polycythemia vera, alongside solid tumors such as breast cancer, lung cancer, and biliary tract cancer.
- Relapsed or refractory multiple myeloma
- Chronic lymphocytic leukemia/small lymphocytic lymphoma
- Myelofibrosis and polycythemia vera
- Non-small cell lung cancer
Infectious disease interests include sepsis, complicated urinary tract infection, gram-negative infections, chronic hepatitis D virus infection, and severe viral lung infections.
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