L.J.A. S.
- Country
- The Netherlands
- Department
- Department of Radiation Oncology
Research Overview
Data & Insights
Has run more than one trial at 0 of 6 partner sites.
Specializations
Thoracic Oncology
Focused on malignant diseases of the lung and mediastinum, integrating advanced radiotherapy techniques to improve local control and survival.
- non-small cell lung cancer
- small cell lung carcinoma
- lung metastases
- mesothelioma
- radiation-induced pneumonitis
Clinical trials are conducted at Amsterdam UMC with a primary emphasis on dose‑escalation and organ‑sparing protocols.
Head and Neck Cancer
Investigates curative and organ‑preserving radiotherapy for tumors of the upper aerodigestive tract.
- oropharyngeal carcinoma
- laryngeal cancer
- nasopharyngeal carcinoma
- salivary gland tumors
- radiation‑associated xerostomia
Research includes combined modality approaches that integrate immunotherapy with stereotactic radiotherapy.
Gastro‑intestinal and Hepatobiliary Oncology
Targets abdominal malignancies where precise radiation delivery is critical for tumor control and organ preservation.
- pancreatic ductal adenocarcinoma
- hepatocellular carcinoma
- cholangiocarcinoma
- rectal cancer
- esophageal adenocarcinoma
Studies evaluate neoadjuvant and definitive radiotherapy regimens adapted to tumor biology.
Neuro‑endocrine and Central Nervous System Tumors
Explores stereotactic and proton‑beam strategies for rare neuro‑endocrine neoplasms and primary brain lesions.
- neuroendocrine carcinoma
- glioblastoma
- brain metastases
- spinal cord compression
- meningioma
Efforts aim to maximize tumor ablation while minimizing neurocognitive sequelae.
Palliation and Symptom Management
Dedicated to alleviating cancer‑related pain, bleeding, and functional impairment through targeted radiation.
- bone metastasis pain control
- hemorrhagic tumor bleeding
- spinal cord compression palliation
- obstructive airway tumors
- quality‑of‑life improvement
These projects leverage short‑course hypofractionated protocols to rapidly relieve symptoms.
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