L. G.
- Country
- Lithuania
- Department
- Hematology
Research Overview
- HOVON 150 AML: A phase 3, multicenter, double-blind, randomized, placebo-controlled study of ivosidenib or enasidenib in combination with induction therapy and consolidation therapy followed by maintenance therapy in patients with newly diagnosed acute myeloid leukemia or myelodysplastic syndrome with excess blasts-2, with an IDH1 or IDH2 mutation, respectively, eligible for intensive chemotherapy.
- HOVON 156 AML: A phase 3, multicenter, open-label, randomized, study of gilteritinib versus midostaurin in combination with induction and consolidation therapy followed by one-year maintenance in patients with newly diagnosed Acute Myeloid Leukemia (AML) or Myelodysplastic syndromes with excess blasts-2 (MDS-EB2) with FLT3 mutations eligible for intensive chemotherapy.
Data & Insights
Has run more than one trial at 104 of 168 partner sites.
Specializations
Hematologic Malignancies
Focus on the treatment and management of blood‑derived cancers.
- Acute Myeloid Leukemia
- Acute Lymphoblastic Leukemia
- Myelodysplastic Syndrome
- Chronic Lymphocytic Leukemia
- Multiple Myeloma
Therapeutic strategies include targeted agents and cellular therapies.
Cardiovascular & Thrombotic Disorders
Research addressing arterial disease, heart failure, and clotting abnormalities.
- Atherosclerotic Cardiovascular Disease
- Acute Coronary Syndrome
- Atrial Fibrillation
- Hemophilia A
- Heparin Resistance
Efforts aim to reduce major adverse cardiac events and bleeding risk.
Renal & Nephrology Conditions
Investigations centered on kidney disease and related complications.
- Chronic Kidney Disease
- Immunoglobulin A Nephropathy
- Proteinuria
- Anemia of Chronic Kidney Disease
- Alport Syndrome
Therapies target renal function preservation and reduction of protein loss.
Autoimmune & Inflammatory Diseases
Studies on systemic and organ‑specific immune‑mediated disorders.
- Rheumatoid Arthritis
- Systemic Lupus Erythematosus
- Inflammatory Bowel Disease
- Idiopathic Inflammatory Myopathy
- Hidradenitis Suppurativa
Interventions explore cytokine inhibition and immune modulation.
Ophthalmic & Vision Disorders
Clinical work on retinal and macular diseases.
- Neovascular Age‑Related Macular Degeneration
- Macular Edema Secondary to Retinal Vein Occlusion
- Diabetic Retinopathy
Goals include improving visual acuity and reducing retinal fluid.
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