Krisztina G.
- Country
- The Netherlands
- Department
- NL10003, Gastroenterology
Research Overview
- Evaluation of Transmural Healing as a Treatment Target in Moderately to Severely Active Crohn's Disease Using Upadacitinib, Risankizumab, and Ustekinumab
- Efficacy and Safety Evaluation of Oral Zasocitinib in Patients with Moderately to Severely Active Crohn's Disease: A Phase 2b Randomized, Double-Blind, Placebo-Controlled Study
- Efficacy of Subcutaneous Infliximab Monotherapy Versus Infliximab with Immunosuppression in Moderate to Severe Crohn's Disease
Data & Insights
Has run more than one trial at 91 of 155 partner sites.
Specializations
Inflammatory Bowel Disease and Digestive Disorders
Clinical research activity centers on Crohn's disease, ulcerative colitis, and related inflammatory bowel disease complications, with additional involvement in eosinophilic esophagitis, primary sclerosing cholangitis, primary biliary cholangitis, and functional constipation.
- Crohn's disease
- Ulcerative colitis
- Primary sclerosing cholangitis
- Eosinophilic esophagitis
Therapeutic interest includes biologic therapy, immune-mediated gastrointestinal disease, and treatment approaches for perianal fistulizing disease and cholestatic pruritus.
Gastrointestinal Oncology and Hepatopancreatobiliary Cancer
The investigator is involved in studies across pancreatic cancer, colorectal cancer, gastric cancer, esophageal cancer, cholangiocarcinoma, and hepatocellular carcinoma, reflecting a strong focus on advanced gastrointestinal malignancies.
- Pancreatic cancer
- Colorectal cancer
- Cholangiocarcinoma
- Esophageal cancer
Therapeutic domains include perioperative treatment, systemic cancer therapy, and management of metastatic solid tumors within the gastroenterology and hepatology interface.
Hematologic Malignancies and Cellular Therapy
Research involvement extends to lymphoma, multiple myeloma, acute myeloid leukemia, myelodysplastic syndrome, and other blood cancers, with attention to both relapsed disease and newly diagnosed settings.
- Diffuse large B-cell lymphoma
- Multiple myeloma
- Acute myeloid leukemia
- Myelodysplastic syndrome
Key therapeutic interests include CAR T-cell therapy, stem cell transplantation, and immunotherapy for aggressive or refractory hematologic disease.
Autoimmune, Fibrotic, and Immune-Mediated Disease
The clinical trial portfolio includes rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis, idiopathic inflammatory myopathy, and myasthenia gravis, alongside fibrotic and inflammatory conditions such as non-alcoholic fatty liver disease with fibrosis and interstitial lung disease.
- Systemic sclerosis
- Idiopathic inflammatory myopathy
- Rheumatoid arthritis
- Systemic lupus erythematosus
Therapeutic emphasis is placed on immune modulation, anti-fibrotic treatment, and disease control in chronic inflammatory disorders.
Cardiometabolic, Pulmonary, and Rare Disease Interests
Additional research activity spans cardiovascular disease, heart failure, atherosclerotic cardiovascular disease, pulmonary arterial hypertension, chronic thromboembolic pulmonary hypertension, chronic kidney disease, and selected rare diseases including hereditary angioedema and fibrodysplasia ossificans progressiva.
- Heart failure
- Pulmonary arterial hypertension
- Chronic kidney disease
- Hereditary angioedema
Therapeutic focus includes cardiometabolic risk reduction, vascular disease, lung vascular disorders, and orphan disease therapy.
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