Kristoffer S. R.
- Country
- Denmark
- Department
- Department of Oncology
Research Overview
- Phase 1 Study of SHP2 Inhibitor BBP-398 and KRAS-G12C Inhibitor Sotorasib in Advanced Solid Tumors with KRAS-G12C Mutation
- Safety, Pharmacokinetics, and Efficacy of RO7567132 Alone and with Atezolizumab in Patients with Advanced or Metastatic Solid Tumors
- Evaluation of Safety, Tolerability, Pharmacokinetics, and Preliminary Anti-Tumor Activity of Inavolisib with Paclitaxel in Locally Advanced or Metastatic Solid Tumors
Data & Insights
Has run more than one trial at 73 of 158 partner sites.
Specializations
Haematologic Malignancies
Clinical research in acute leukaemias, lymphomas, and multiple myeloma forms a major part of this investigator’s work, with interest across relapsed, refractory, and newly diagnosed blood cancers.
- Acute lymphoblastic leukaemia
- Acute myeloid leukaemia
- Diffuse large B-cell lymphoma
- Chronic lymphocytic leukaemia
- Multiple myeloma
The therapeutic focus also includes Hodgkin lymphoma, mantle cell lymphoma, small lymphocytic lymphoma, and other B-cell and T-cell malignancies.
Solid Tumours and Precision Oncology
The investigator is active in studies of advanced solid tumours and tumour-specific targeted treatment strategies, especially across thoracic, gastrointestinal, breast, genitourinary, and gynaecological cancers.
- Non-small cell lung cancer
- Colorectal cancer
- Breast cancer
- Prostate cancer
- Endometrial cancer
Research interests extend to urothelial carcinoma, ovarian cancer, esophageal cancer, pancreatic cancer, and molecularly defined disease groups involving KRAS, HER2, MTAP, and RET alterations.
Neurology and Neuro-Oncology
Work in neurology and neuro-oncology includes both malignant and non-malignant disorders, with attention to aggressive brain tumours and chronic neurological disease.
- Glioblastoma
- Medulloblastoma
- Multiple sclerosis
- Myasthenia gravis
- Alzheimer’s disease
Additional interest is seen in diffuse midline glioma, ependymoma, migraine, trigeminal neuralgia, stroke, and traumatic brain injury.
Cardiovascular and Pulmonary Medicine
The investigator is involved in clinical research on cardiovascular disease and pulmonary disorders, spanning acute events, chronic syndromes, and vascular complications.
- Myocardial infarction
- Heart failure
- Atrial fibrillation
- Pulmonary arterial hypertension
- Chronic obstructive pulmonary disease
Therapeutic interests also cover atherosclerotic cardiovascular disease, aortic stenosis, pulmonary embolism, idiopathic pulmonary fibrosis, and bronchiectasis.
Autoimmune, Renal, and Rare Diseases
This investigator also contributes to studies in autoimmune disease, renal disease, and selected rare disorders, reflecting a broad interest in immune-mediated and inherited conditions.
- Systemic lupus erythematosus
- Rheumatoid arthritis
- IgA nephropathy
- Chronic kidney disease
- Myasthenia gravis
Additional therapeutic areas include Crohn’s disease, ulcerative colitis, systemic sclerosis, haemophilia, and muscular dystrophy.
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