Kristine B.
- Country
- Latvia
- Department
- Ophtalmology
Research Overview
- A Randomized, Double-masked Study Comparing the Efficacy and Safety of AVT29 Versus High-Dose Aflibercept in Participants with Diabetic Macular Edema
- Long-Term Extension Study of Imeroprubart in Adult Patients With Graves' Disease
- Randomized, Double‑Masked, Multicenter Phase 2/3 Trial of Intravitreal MK‑8748 versus Aflibercept in Neovascular Age‑Related Macular Degeneration
Data & Insights
Has run more than one trial at 174 of 288 partner sites.
Specializations
Retinal and Macular Disease
Clinical research activity in ophthalmology includes treatment areas centered on neovascular age-related macular degeneration, diabetic macular edema, macular edema secondary to retinal vein occlusion, and broader chorioretinal vascular disease.
- Wet AMD
- Diabetic macular edema
- Retinal vein occlusion
- Chorioretinal vascular disease
The trial portfolio also includes comparative interest in intravitreal anti-VEGF therapy and biosimilar approaches for retinal disorders.
Thyroid Eye Disease and Ocular Inflammation
Another major focus is thyroid eye disease, with attention to proptosis control, ocular symptom burden, and longer-term disease management within the orbital inflammatory disease spectrum.
- Thyroid eye disease
- Proptosis
- Orbital inflammation
- Ocular safety
Research interests in this area reflect involvement in newer targeted options for active ophthalmic autoimmune disease.
Cardiovascular Thrombosis and Stroke Prevention
Clinical studies also extend into cardiovascular medicine, particularly atrial fibrillation, acute ischemic stroke, transient ischemic attack, acute myocardial infarction, and atherosclerotic cardiovascular disease.
- Atrial fibrillation
- Stroke prevention
- Acute coronary syndrome
- Myocardial infarction
Therapeutic interest includes antithrombotic strategies and prevention of recurrent embolic and ischemic events.
Autoimmune and Inflammatory Disease
Investigations include systemic immune-mediated conditions such as systemic lupus erythematosus, psoriatic arthritis, relapsing multiple sclerosis, and Graves’ disease.
- Systemic lupus erythematosus
- Psoriatic arthritis
- Relapsing multiple sclerosis
- Graves’ disease
This area links immune modulation with both systemic and eye-related manifestations of autoimmune illness.
Oncology and Respiratory Medicine
Research involvement also covers non-small cell lung cancer, small cell lung cancer, glioblastoma, gastric and gastroesophageal junction adenocarcinoma, and prostate cancer, alongside asthma and chronic obstructive pulmonary disease.
- Non-small cell lung cancer
- Glioblastoma multiforme
- Prostate cancer
- Asthma
The clinical landscape includes therapies for advanced malignancy, perioperative cancer care, and inflammatory airway disease.
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