Krister L.
- Country
- Sweden
- Department
- VO Hjärt-Fysiologi
Research Overview
- Evaluation of Balcinrenone and Dapagliflozin on Cardiovascular Outcomes in Heart Failure Patients with Renal Impairment: A Phase III Randomized, Double-Blind Study
- Phase 2b Open-Label Study Evaluating Tolerability and Safety of 5 mg Vericiguat in Chronic Heart Failure with Reduced Ejection Fraction
- Evaluation of Eplerenone, Altizide, and Micronised Spironolactone in Heart Failure with Reduced Ejection Fraction and Severe Chronic Kidney Disease
Data & Insights
Has run more than one trial at 17 of 252 partner sites.
Specializations
Cardiovascular disease and thrombosis
Clinical work includes atrial fibrillation, acute myocardial infarction, stroke prevention, left ventricular thrombus, takotsubo syndrome, heart failure, and broader atherosclerotic cardiovascular disease. The portfolio also covers hypertension, high cardiovascular risk, and cardiomyopathy.
- Stroke and embolic risk reduction
- Heart failure and cardiovascular death
- Antithrombotic treatment in arrhythmia
- Blood pressure control
Therapeutic interests extend across anticoagulation, antiplatelet therapy, and emerging approaches for cardiorenal protection.
Kidney disease and cardiorenal syndromes
Research involvement includes chronic kidney disease, IgA nephropathy, C3 glomerulopathy, focal segmental glomerulosclerosis, and ANCA-associated vasculitis with renal involvement. Related work also addresses proteinuria and progression of kidney failure.
- Glomerular disease
- Renal function preservation
- Complement-mediated kidney disease
- Hypertension with kidney impairment
The therapeutic landscape includes renal disease modification in patients with overlapping cardiac and metabolic risk.
Inflammatory bowel disease and hepatobiliary inflammation
Areas of interest include Crohn's disease, ulcerative colitis, and primary sclerosing cholangitis, with additional attention to associated colorectal cancer risk in inflammatory disease settings. The clinical focus spans chronic intestinal inflammation and immune-mediated hepatobiliary disease.
- Crohn's disease
- Ulcerative colitis
- Primary sclerosing cholangitis
- Colorectal cancer in inflammatory disease
Therapeutic activity is centered on immune-mediated gastrointestinal disease and long-term disease control.
Acute neurological and critical care conditions
Clinical trial involvement includes acute ischemic stroke, intracerebral hemorrhage, transient ischemic attack, thrombolysis in stroke care, and intensive care unit interventions. The portfolio also includes severe viral lung infections and critical illness.
- Acute stroke treatment
- Hemorrhagic stroke management
- Critical care interventions
- Severe respiratory infection
The therapeutic emphasis is on urgent hospital-based care for neurologic and life-threatening inflammatory conditions.
Women’s health and reproductive medicine
Research participation includes preeclampsia, labour induction, contraception, primary dysmenorrhea, vulvovaginal atrophy, and menopausal hormone therapy. Additional interest extends to postpartum and post-abortion reproductive care.
- Preeclampsia and pregnancy care
- Contraception and family planning
- Menstrual pain and vulvovaginal symptoms
- Hormonal therapy safety
Therapeutic involvement spans obstetric, gynecologic, and hormonal care domains.
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