Krischan B.
- Country
- Germany
- Department
- Klinik und Poliklinik für innere Medizin III
Research Overview
- International Euro Ewing (iEuroEwing) trial for treatment optimisation in patients with Ewing sarcoma
- Phase III Evaluation of Onfekafusp Alfa and Doxorubicin Versus Doxorubicin Monotherapy in Advanced or Metastatic Soft Tissue Sarcoma
- Evaluation of Onfekafusp Alfa and Dacarbazine in Advanced or Metastatic Soft-Tissue Sarcoma Post-Two Systemic Therapies
Data & Insights
Has run more than one trial at 33 of 122 partner sites.
Specializations
Myeloid malignancies
Clinical research in acute myeloid leukemia, myelodysplastic syndromes, chronic myelomonocytic leukemia, and related high-risk myeloid disorders, with emphasis on refractory disease, molecular relapse, and treatment options before or after stem cell transplantation.
- Acute myeloid leukemia
- Myelodysplastic syndromes
- Chronic myelomonocytic leukemia
- Allogeneic hematopoietic cell transplantation
Also includes interest in anemia management in lower-risk myelodysplasia and therapeutic strategies for patients with limited response to prior hypomethylating agent treatment.
Hematologic and lymphoid cancers
Investigational work in multiple myeloma, lymphoma, chronic lymphocytic leukemia, acute lymphoblastic leukemia, and other B-cell malignancies, covering both newly diagnosed and relapsed or refractory settings.
- Multiple myeloma
- B-cell malignancies
- Chronic lymphocytic leukemia
- Acute lymphoblastic leukemia
The portfolio also extends to mantle cell lymphoma, follicular lymphoma, marginal zone lymphoma, and primary central nervous system lymphoma.
Solid tumors and precision oncology
Active involvement in trials for breast cancer, prostate cancer, lung cancer, gastroesophageal cancer, colorectal cancer, and renal cell carcinoma, with attention to advanced, metastatic, and biomarker-defined disease.
- Breast cancer
- Prostate cancer
- Gastroesophageal adenocarcinoma
- Non-small cell lung cancer
Research interests also include hepatocellular carcinoma, urothelial cancer, ovarian cancer, head and neck squamous cell carcinoma, and melanoma.
Transplantation and cellular therapy
Clinical activity in hematopoietic stem cell transplantation, graft-versus-host disease, and post-transplant infectious complications, alongside studies of gene-modified T cells and other advanced cellular therapies.
- Graft-versus-host disease
- Gene-modified T cells
- Post-transplant infection
- Peripheral blood stem cell transplantation
The therapeutic focus includes transplant optimization, immune recovery, and management of complications after allogeneic transplantation.
Non-oncology therapeutic areas
Research involvement also spans neurology, nephrology, cardiology, infectious diseases, and inflammatory disorders, reflecting interest in complex medical conditions beyond cancer care.
- Alzheimer’s disease
- Multiple sclerosis
- Chronic kidney disease
- Inflammatory bowel disease
Additional areas include HIV-1 infection, heart failure, autoimmune skin disease, and chronic pain.
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