Kremena G.
- Country
- Bulgaria
- Department
- N/A
Research Overview
- A Phase 2 Dose Finding Study Evaluating the Safety and Efficacy of Linaclotide in Pediatric Subjects 6 Months to Less Than 2 Years of Age with Functional Constipation (FC).
- A Phase 3, Multicenter, Randomized, Double-blind, Parallel-group, Safety and Efficacy Study of Linaclotide versus Placebo in Pediatric Subjects, Ages 2 to 5 Years, with Functional Constipation (FC) with a 24-week Open-label Treatment Extension
Data & Insights
Has run more than one trial at 5 of 15 partner sites.
Specializations
Pediatric Gastroenterology and Inflammatory Bowel Disease
Clinical research activity includes treatment areas centered on Crohn’s disease, ulcerative colitis, and related pediatric intestinal disorders, with attention to both disease control and long-term therapeutic management.
- Pediatric functional constipation
- Moderately to severely active Crohn’s disease
- Ulcerative colitis and inflammatory bowel disease
- Vedolizumab and risankizumab in pediatric care
- Upadacitinib for pediatric intestinal inflammation
The research profile also includes pediatric pharmacokinetics and long-term safety evaluation in children with chronic gastrointestinal disease.
Cardiovascular Disease and Thromboembolic Risk
Another major area of interest is atrial fibrillation, including persistent symptomatic disease and strategies aimed at reducing arrhythmic recurrence and stroke risk in patients who are not suitable for standard anticoagulation.
- Atrial fibrillation management
- Persistent symptomatic atrial fibrillation
- Catheter ablation and rhythm control
- Stroke prevention in high-risk atrial fibrillation
- Hypertrophic cardiomyopathy
Work in this domain also extends to symptomatic hypertrophic cardiomyopathy, reflecting involvement in structural and rhythm-related cardiac conditions.
Hematology, Oncology, and Immune-Mediated Disorders
Clinical trial involvement spans malignant and immune-driven diseases, including lymphoid malignancies, breast cancer, and inflammatory skin and joint disorders.
- Diffuse large B-cell lymphoma
- Follicular lymphoma
- Metastatic breast cancer
- Atopic dermatitis
- Polyarticular-course juvenile idiopathic arthritis
This therapeutic area also includes interest in immunotherapy, targeted treatment, and chronic immune-mediated disease control.
Neurology and Autoimmune Disease
The investigator is also involved in studies addressing chronic neurologic and autoimmune conditions, with focus on disease stability, symptom control, and long-term treatment use.
- Multiple sclerosis
- Refractory focal onset seizures
- Ocrelizumab in multiple sclerosis
- Levetiracetam in drug-resistant epilepsy
- Filgotinib in juvenile arthritis
These activities reflect engagement with chronic inflammatory and neurologic diseases requiring sustained therapeutic oversight.
Nephrology, Endocrinology, and Metabolic Disease
Research interests further extend to kidney disease, growth disorders, liver disease, and metabolic conditions across pediatric and adult populations.
- Chronic kidney disease with proteinuria
- Anemia associated with chronic kidney disease
- Non-alcoholic steatohepatitis
- Childhood growth disorders
- Obesity and type 2 diabetes
The portfolio also includes hepatic and metabolic therapeutic areas, alongside pediatric growth and renal complications.
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