Krasimira S.
- Country
- Bulgaria
- Department
- Department of Rheumatology
Research Overview
- A Phase 3 Open-Label Extension Study to Evaluate the Long-Term Safety, Tolerability, and Efficacy of Subcutaneous Sonelokimab in Participants With Psoriatic Arthritis
- A Randomized, Multi-regional, Double-blind, Double-dummy Parallel-group, Placebo and Allopurinol-controlled Phase 3 Study to Assess the Efficacy and Safety of Tigulixostat in Gout Patients with Hyperuricemia
- Long-Term Safety and Efficacy Evaluation of Filgotinib in Rheumatoid Arthritis: An Open-Label Extension Study
Data & Insights
Has run more than one trial at 142 of 248 partner sites.
Specializations
Rheumatoid arthritis and related inflammatory disease
Clinical research activity is centered on rheumatoid arthritis, including ACPA-positive rheumatoid arthritis and other active inflammatory presentations. The investigator is involved in studies of disease control, symptom reduction, and treatment durability in chronic autoimmune rheumatic disease.
- Rheumatoid arthritis
- ACPA-positive rheumatoid arthritis
- Autoimmune inflammation
Work in this area also extends to therapies aimed at improving joint function and reducing persistent inflammatory burden in patients with active disease.
Psoriatic arthritis and axial spondyloinflammatory disease
The investigator has a strong therapeutic focus on psoriatic arthritis, including active peripheral disease and axial involvement. This includes interest in biologic and targeted approaches for controlling musculoskeletal inflammation, pain, and functional impairment.
- Psoriatic arthritis
- Axial disease
- Biologic therapy
Research activity in this field reflects a sustained emphasis on managing chronic inflammatory arthropathy and improving disease-related symptoms.
Metabolic and lipid disorders
Another key area of involvement is hypertriglyceridemia, including severe forms associated with elevated cardiometabolic risk and pancreatitis concern. The investigator is engaged in studies addressing lipid lowering and broader metabolic risk management.
- Severe hypertriglyceridemia
- Hypertriglyceridemia
- Acute pancreatitis risk
This therapeutic domain also includes gout with hyperuricemia, linking inflammatory and metabolic care in chronic disease management.
Bone, connective tissue, and pain disorders
Clinical interests also include osteoporosis and musculoskeletal pain conditions such as moderate to severe rotator cuff tendinopathy. The investigator is involved in research on pain relief, structural support, and functional recovery across rheumatologic and orthopedic conditions.
- Osteoporosis
- Rotator cuff tendinopathy
- Postoperative pain
Additional activity spans post-herpetic neuralgia and endometriosis-related pain, highlighting interest in both chronic and procedure-related pain management.
Systemic autoimmune and selected internal medicine conditions
The investigator’s portfolio includes Sjögren's disease, progressive multiple sclerosis, and asthma, reflecting engagement beyond rheumatology into immune-mediated and respiratory disease. There is also involvement in studies related to venous thromboembolism and reversal of anticoagulation effect in urgent surgical settings.
- Sjögren's disease
- Progressive multiple sclerosis
- Asthma
- Venous thromboembolism
These areas indicate participation in therapeutic research across systemic autoimmunity, respiratory disease, and anticoagulation-related care.
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