Krasimira H. T.
- Country
- Bulgaria
- Department
- NA
Research Overview
- Evaluation of Tovinontrine on NT-proBNP Levels in Adults with Chronic Heart Failure with Preserved Ejection Fraction: A Phase 2 Randomized, Double-Blind, Placebo-Controlled Study
- Phase 2 Randomized Double-Blind Placebo-Controlled Study of Tovinontrine in Adults with Heart Failure with Reduced Ejection Fraction
- Evaluation of the Efficacy and Safety of BI 690517 and Empagliflozin in Patients with Symptomatic Heart Failure and LVEF ≥40%: A Phase III Randomized Controlled Trial
Data & Insights
Has run more than one trial at 262 of 696 partner sites.
Specializations
Atherosclerotic Cardiovascular Disease & Risk Management
Targeted studies aim to lower the incidence of major adverse cardiovascular events in high‑risk adults.
- Major adverse cardiovascular events
- Coronary heart disease mortality
- Ischemic stroke prevention
Research includes patients with established atherosclerotic cardiovascular disease and those at elevated risk without prior myocardial infarction.
Heart Failure Therapeutics
Clinical work focuses on improving outcomes for both preserved and reduced ejection fraction heart failure.
- Heart failure with preserved ejection fraction
- Heart failure with reduced ejection fraction
- Hospitalization for heart failure
Investigations address symptomatic chronic heart failure across a range of ejection fractions.
Lipid Metabolism Disorders
Efforts concentrate on reducing triglyceride levels and managing severe hypertriglyceridemia.
- Severe hypertriglyceridemia
- Fasting triglyceride reduction
- Lipid‑modifying therapy optimization
Studies involve patients with elevated triglycerides despite standard lipid‑lowering regimens.
Diabetes, Hypertension & Metabolic Syndrome
Research integrates glucose control, blood pressure management, and cardiovascular risk reduction.
- Type 2 diabetes management
- Hypertension control
- Cardiovascular disease in metabolic syndrome
Trials evaluate therapeutic combinations in individuals with type 2 diabetes, hypertension, and established cardiovascular disease.
Juvenile Inflammatory Arthritis
Focused investigations assess novel agents for pediatric arthritis subtypes.
- Juvenile psoriatic arthritis
- Polyarticular‑course juvenile idiopathic arthritis
- Pediatric safety and efficacy
Work targets children and adolescents diagnosed with juvenile psoriatic arthritis or related juvenile idiopathic conditions.
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