Koen D.
- Country
- Belgium
- Department
- 4201: Medical Oncology
Research Overview
- Phase III Study of Datopotamab Deruxtecan Versus Docetaxel in Patients With Previously Treated TROP2-Positive Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer
- Open‑Label Rollover Study of Opnurasib (JDQ443) Monotherapy or Combination Therapy in Patients with KRAS G12C‑Mutated Advanced NSCLC or Solid Tumors
- Phase 2 Open-Label Study on Safety and Efficacy of Telisotuzumab Vedotin in c-Met Positive Non-Small Cell Lung Cancer Patients with Prior Treatment
Data & Insights
Has run more than one trial at 95 of 291 partner sites.
Specializations
Thoracic Oncology
Clinical research in non-small cell lung cancer, small cell lung cancer, and pleural mesothelioma, with interest in advanced, metastatic, resectable, and biomarker-defined disease settings.
- Non-small cell lung cancer
- Small cell lung cancer
- Pleural mesothelioma
- RET fusion-positive lung cancer
- c-Met overexpressing lung cancer
Work also spans immunotherapy, targeted therapy, and combination approaches for lung malignancies.
Head and Neck Cancer
Active involvement in head and neck squamous cell carcinoma, including locally advanced, recurrent, metastatic, and resected disease, with emphasis on treatment strategies in curative and advanced settings.
- Head and neck squamous cell carcinoma
- Locoregionally advanced disease
- Recurrent or metastatic disease
- Resected squamous cell carcinoma
- HPV-negative head and neck cancer
Therapeutic interests include checkpoint inhibition, perioperative treatment, and combination systemic therapy.
Gastroenterology and Inflammatory Bowel Disease
Research activity includes Crohn's disease, ulcerative colitis, and related inflammatory bowel disease phenotypes, with attention to postoperative recurrence and persistent active disease.
- Crohn's disease
- Ulcerative colitis
- Inflammatory bowel disease
- Postoperative recurrence
- Transmural healing
The portfolio also reflects interest in biologic therapy and disease control after intestinal surgery.
Breast, Ovarian, and Gynecologic Oncology
Clinical trial involvement covers breast cancer, ovarian cancer, and endometrial cancer, including hormone receptor-positive, HER2-negative, triple-negative, and high-risk molecular subgroups.
- Breast cancer
- Ovarian cancer
- Endometrial cancer
- Triple-negative breast cancer
- HER2-negative disease
Research interests include endocrine therapy, maintenance treatment, and biomarker-informed approaches in women’s cancers.
Hematologic Malignancies and Uro-Oncology
Additional work includes lymphoma, multiple myeloma, and bladder cancer, alongside interest in relapsed, refractory, and high-risk disease states.
- Diffuse large B-cell lymphoma
- Mantle cell lymphoma
- Relapsed or refractory multiple myeloma
- Non-muscle-invasive bladder cancer
- High-risk urothelial carcinoma
The therapeutic focus extends to immunomodulatory and targeted anticancer therapies in both hematologic and urologic oncology.
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