Koen L.

Investigates antithrombotic and lipid‑lowering interventions for patients with atrial fibrillation and established atherosclerotic cardiovascular disease.

• Stroke prevention in atrial fibrillation
• Secondary prevention after percutaneous coronary intervention
• LDL‑C reduction with inclisiran
• Management of resistant hypertension
• Outcomes after aortic valve replacement

Trials compare novel oral anticoagulants, RNA‑based therapies, and antiplatelet regimens to standard care.

Addresses therapeutic options for chronic and acute respiratory disease, including chronic obstructive pulmonary disease and severe community‑acquired pneumonia.

• Exacerbation reduction in COPD
• Mortality impact of immunomodulators in severe pneumonia
• Ventilation strategies during cardiac surgery
• Pulmonary embolism prevention post‑cardiac procedures
• Biomarker‑guided therapy in acute lung injury

Studies evaluate anti‑inflammatory agents, antimicrobial stewardship, and peri‑operative respiratory protocols.

Explores biologic and small‑molecule treatments for moderate to severe Crohn’s disease and ulcerative colitis.

• Efficacy of anti‑IL‑23 agents in Crohn’s disease
• Long‑term safety of ustekinumab
• Post‑surgical recurrence prevention in IBD
• Endoscopic remission endpoints
• Combination therapy with immunomodulators

Trials incorporate endoscopy‑driven versus systematic biologic initiation strategies.

Focuses on analgesic protocols and goal‑directed fluid management for surgical patients, including those undergoing DIEP free flap breast reconstruction and cardiac procedures.

• Axial pain tapering for chronic low back pain
• Interpectoral‑pectoserratus plane block in aortic valve replacement
• Goal‑directed fluid therapy during major surgery
• Hemodynamic optimization in flap surgery
• Opioid‑sparing analgesia pathways

Research integrates multimodal analgesia and intra‑operative monitoring to enhance recovery.