Loes V.
- Country
- The Netherlands
- Department
- Internal medicine
Research Overview
Data & Insights
Has run more than one trial at 0 of 42 partner sites.
Specializations
Oncology
The investigator is engaged in clinical research targeting solid tumours such as breast cancer, colorectal cancer, and esophagogastric cancer.
- Evaluation of HER2‑targeted regimens in HER2‑positive breast cancer
- Assessment of neoadjuvant chemotherapy de‑escalation in early‑stage colorectal cancer
- Investigation of organ‑preserving approaches for early rectal cancer
- Combination immunotherapy in dMMR esophagogastric cancer
Emphasis is placed on therapeutic strategies that improve survival and reduce treatment‑related toxicity.
Cardiovascular & Renal
Research activities include patients with high cardiovascular risk, focusing on dyslipidemia and the composite outcome of kidney failure, hospitalization for heart failure, and all‑cause mortality.
- Aspirin adjunct therapy in patients with respiratory infection to prevent acute coronary syndrome
- Dapagliflozin efficacy on renal and cardiovascular outcomes in severe chronic kidney disease
- LDL‑C lowering strategies using obecetrapib versus bempedoic acid
The work seeks to integrate novel agents with standard care to mitigate adverse cardiovascular events.
Pulmonary & Infectious Diseases
The investigator examines acute and chronic respiratory conditions, including chronic obstructive pulmonary disease, community‑acquired pneumonia, and influenza.
- Tozorakimab as anti‑exacerbation therapy in COPD
- Platform trial evaluating interventions for acute respiratory tract infection
- Aspirin to lower cardiovascular complications in pneumonia or influenza
Objectives center on reducing exacerbations and improving survival in hospitalized patients.
Endocrine & Metabolic Disorders
Clinical interest extends to hormonal disorders such as polycystic ovary syndrome and autonomous thyroid nodules, as well as metabolic risk factors.
- Letrozole versus gonadotropin stimulation in PCOS
- Radiofrequency ablation versus radioactive iodine for hyperactive thyroid nodules
- Impact of CDK4/6 inhibition combined with aromatase inhibitors in hormone‑responsive breast cancer
Studies aim to optimize fertility outcomes and compare ablative techniques for hyperthyroidism.
Hematology & Immunology
The investigator also contributes to trials in hematologic malignancies, focusing on multiple myeloma and chronic lymphocytic leukemia.
- Treatment‑free interval feasibility in multiple myeloma receiving daratumumab‑lenalidomide‑dexamethasone
- Venetoclax continuation versus discontinuation in CLL
- Immunotherapy sequencing in relapsed/refractory CLL
Therapeutic goals include achieving deep remission while managing treatment‑free intervals.
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