Keikawus A.
- Country
- Germany
- Department
- NA
Research Overview
- A Phase 3b Study Comparing Dolutegravir/Lamivudine to Bictegravir/Emtricitabine/Tenofovir Alafenamide in Antiretroviral-Naive Adults with HIV
- Phase 3 Randomized Double-Blind Placebo-Controlled Trial of Efruxifermin in Non-Cirrhotic NASH/MASH with Fibrosis
- Efficacy and Safety Evaluation of GSK4532990 in Adults with Alcohol-Related Liver Disease: A Phase 2, Double-Blind, Placebo-Controlled, Dose-Finding Study
Data & Insights
Has run more than one trial at 109 of 283 partner sites.
Specializations
HIV Treatment and Antiretroviral Therapy
Clinical research activity includes HIV-1 infection, human immunodeficiency virus management, and treatment strategies for both treatment-naïve and virologically suppressed individuals, with attention to regimen switching and long-term viral control.
- Antiretroviral efficacy
- Virologic suppression
- Therapy switching
- Safety and tolerability
The therapeutic focus extends to compact oral regimens and durable control of HIV infection in adult populations.
Chronic Hepatitis B and Viral Cure Strategies
Research involvement covers chronic hepatitis B and hepatitis B management, including efforts aimed at functional cure, immune-based approaches, and long-term durability after treatment cessation.
- Functional cure
- HBsAg reduction
- Immune-mediated control
- Durability of response
This area reflects a strong therapeutic interest in advancing HBV care beyond standard nucleos(t)ide analogue treatment.
Liver Disease, NASH, and MASH
The investigator is active in studies of liver diseases linked to alcoholic liver disease, non-alcoholic steatohepatitis, and metabolic dysfunction-associated steatohepatitis, with emphasis on fibrosis-related liver injury and disease resolution.
- Fibrosis regression
- Steatohepatitis resolution
- Alcohol-related liver disease
- Metabolic liver injury
These trials align with therapeutic development in progressive liver disease and outcomes linked to fibrosis improvement.
Gastrointestinal Infection and Microbiome-Related Disease
Clinical interests include prevention of recurrent Clostridioides difficile infection, with work centered on relapse reduction and restoration of intestinal stability.
- Recurrent CDI
- Infection prevention
- Gut microbial restoration
The therapeutic domain addresses infectious disease recurrence and microbiome-directed intervention.
Immune-Mediated and Vaccine Research
Additional research activity spans primary IgA nephropathy, respiratory syncytial virus infections, and human papillomavirus prevention through adult vaccination studies.
- IgA nephropathy
- RSV prevention
- HPV oral infection prevention
- Immune response
This portfolio includes both immune-mediated kidney disease and adult vaccination strategies for infectious disease prevention.
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