Kathrin B.
- Country
- Germany
- Department
- Klinik für Neurologie
Research Overview
- Randomized, Double‑Blind, Placebo‑Controlled 104‑Week Proof‑of‑Concept Study of IV Prasinezumab in GBA‑Mutation Parkinson’s Disease Assessing Cognitive Decline
- Efficacy Evaluation of Intravenous Prasinezumab (RO7046015) in Early Idiopathic Parkinson's Disease: A Randomized, Double-Blind, Placebo-Controlled Phase II Study
- A Phase III, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Evaluate the Efficacy and Safety of Intravenous Prasinezumab in Participants with Early-Stage Parkinson’s Disease
Data & Insights
Has run more than one trial at 17 of 90 partner sites.
Specializations
Neurodegenerative Disorders
The investigator concentrates on progressive neuronal loss conditions, encompassing Alzheimer’s disease, Parkinson’s disease, Huntington disease and Multiple system atrophy.
- Pathophysiology of protein aggregation in neurodegeneration
- Biomarker development for early disease detection
- Therapeutic targeting of alpha‑synuclein and tau
- Longitudinal clinical phenotyping of atypical presentations
Collaboration with translational laboratories supports mechanistic insight.
Movement Disorders & Parkinsonism
Research addresses motor circuit dysfunctions, including idiopathic Parkinson’s disease, drug‑induced parkinsonism and essential tremor.
- Neuroimaging of basal ganglia circuitry
- Genetic modifiers of disease progression
- Non‑motor symptom profiling
- Device‑assisted therapy optimization
Efforts aim to refine patient stratification for emerging interventions.
Dementia & Cognitive Decline
The focus includes diverse cognitive impairment syndromes such as vascular dementia, Lewy body dementia and early‑onset Alzheimer’s disease.
- Cerebrovascular contributions to cognitive impairment
- Neuropsychological test battery validation
- Synaptic dysfunction biomarkers
- Impact of comorbid neuropsychiatric conditions
Data integration across imaging and fluid biomarkers enhances diagnostic accuracy.
Rare Neuromuscular & Ataxia Syndromes
Investigation of hereditary ataxias and related neuromuscular disorders, notably Friedreich ataxia, Spinocerebellar ataxia type 3 and Kearns‑Sayre syndrome.
- Genotype‑phenotype correlation studies
- Mitochondrial dysfunction assessment
- Natural history cohort establishment
- Exploratory therapeutic repurposing trials
Patient registries support rare disease network initiatives.
Neuroinflammation & Autoimmune Neurology
Explores inflammatory central nervous system disorders, including multiple sclerosis, acute disseminated encephalomyelitis and autoimmune encephalitis.
- Immune cell profiling in cerebrospinal fluid
- Therapeutic impact of B‑cell depletion
- Imaging of blood‑brain barrier integrity
- Long‑term outcome tracking after immunotherapy
Integration of clinical and immunological data guides precision treatment strategies.
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