Karima Y.
- Country
- France
- Department
- Hematology-Immunology
Research Overview
Data & Insights
Has run more than one trial at 0 of 11 partner sites.
Specializations
Hematologic Malignancies
The investigator focuses on leukemia and lymphoma across pediatric and adolescent populations, emphasizing disease subtypes with high therapeutic need.
- Acute Lymphoblastic Leukemia
- Acute Myeloid Leukemia
- Chronic Myeloid Leukemia
- High‑risk B‑cell ALL
- Classical Hodgkin lymphoma
These targets drive innovative approaches in cellular therapy and targeted agents.
Immune‑Mediated Disorders
Key interests include autoimmune and inflammatory conditions where immune modulation is central.
- Immune Thrombocytopenia
- Chronic Graft‑Versus‑Host Disease
- Behçet’s disease
- Familial Mediterranean Fever
- Autoimmune hemolytic disorders
Research integrates novel biologics and cellular products to restore immune balance.
Transplantation & Graft‑Versus‑Host Disease
Expertise spans solid‑organ and hematopoietic stem cell transplantation, with emphasis on post‑transplant complications.
- Allogeneic stem cell transplantation
- Renal allograft management
- Thrombotic microangiopathy after HSCT
- Viral reactivation in transplant recipients
- Desensitization strategies for highly sensitized patients
These studies aim to improve graft survival and reduce morbidity.
Metabolic & Endocrine Disorders
Investigation targets rare and common metabolic diseases affecting growth and systemic health.
- Primary Hyperoxaluria
- Congenital adrenal hyperplasia
- Generalised lipodystrophy
- Obesity in youth
- Cushing’s disease
Therapeutic efforts include enzyme replacement and metabolic pathway modulation.
Pediatric Respiratory & Neurological Disorders
Focus includes severe airway disease and refractory epilepsies in children.
- Severe eosinophilic asthma
- Asthma exacerbations
- Tuberous sclerosis complex‑related epilepsy
- Developmental and epileptic encephalopathies
- Autism spectrum disorder with gastrointestinal symptoms
Clinical work seeks to reduce disease burden through targeted biologics and novel anticonvulsants.
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