K. D. H.
- Country
- Germany
- Department
- Interne geneeskunde
Research Overview
- HOVON 158 CLL: First line treatment with VeNEtoclaX and ibruTinib induction followed by obinutuzumab intenSificaTion Exclusively in CLL/SLL Patients not in complete remission and/or with detectable bone marrow minimal residual disease (NEXT STEP trial)
- HOVON 156 AML: A phase 3, multicenter, open-label, randomized, study of gilteritinib versus midostaurin in combination with induction and consolidation therapy followed by one-year maintenance in patients with newly diagnosed Acute Myeloid Leukemia (AML) or Myelodysplastic syndromes with excess blasts-2 (MDS-EB2) with FLT3 mutations eligible for intensive chemotherapy.
- HOVON 152 DLBCL. A phase II study evaluating the effect of DA-EPOCH-R induction followed by nivolumab consolidation in patients with newly diagnosed high grade B cell lymphoma (HGBL) with MYC and BCL2 and/or BCL6 rearrangements
Data & Insights
Has run more than one trial at 20 of 156 partner sites.
Specializations
Hematologic Malignancies
Acute Myeloid Leukemia and related myeloid neoplasms are central to this portfolio. Chronic Lymphocytic Leukemia represents a focus on indolent lymphoid disease. Myelodysplastic Neoplasia is addressed through targeted therapeutic strategies.
- Acute Myeloid Leukemia
- Chronic Lymphocytic Leukemia
- Myelodysplastic Neoplasia
- Diffuse Large B-Cell Lymphoma
- Follicular Lymphoma
Research conducted at Universitaetsklinikum Ulm AöR and Flevoziekenhuis Stichting.
Solid Tumor Oncology
Breast Cancer is a primary target across early and advanced stages. Head and Neck Squamous Cell Carcinoma is explored with organ‑preserving approaches. Colorectal Cancer and Esophageal Adenocarcinoma are investigated using immunotherapy combinations.
- Breast Cancer
- Head and Neck Squamous Cell Carcinoma
- Colorectal Cancer
- Esophageal Adenocarcinoma
- Ewing Sarcoma
Collaborative trials span European and international sites.
Immunology and Allergy
Atopic Eczema is studied with novel biologic agents. Peanut Allergy research focuses on desensitization protocols. Hereditary Angioedema trials assess subcutaneous therapeutic options.
- Atopic Eczema
- Peanut Allergy
- Hereditary Angioedema
- Paroxysmal Nocturnal Hemoglobinuria
- Influenza
Studies integrate immunologic biomarkers for patient stratification.
Metabolic and Endocrine Disorders
Type 1 Diabetes Mellitus is a key area for beta‑cell preservation strategies. Beta‑Thalassemia research emphasizes transfusion‑independent outcomes. Obesity trials evaluate adjunctive pharmacologic interventions.
- Type 1 Diabetes Mellitus
- Beta‑Thalassemia
- Obesity
- Polycystic Ovary Syndrome
- Generalised Lipodystrophy
Trials evaluate novel agents to improve metabolic control and quality of life.
Ophthalmology and Vascular Medicine
Exudative Age‑Related Macular Degeneration is addressed with anti‑VEGF and procedural therapies. Macular Edema due to Central Retinal Vein Occlusion studies explore laser adjuncts. Ischemic Stroke research includes secondary prevention strategies.
- Exudative Age‑Related Macular Degeneration
- Macular Edema due to Central Retinal Vein Occlusion
- Ischemic Stroke
- Myocardial Infarction
- Cardiovascular Outcomes in Chronic Kidney Disease
Multidisciplinary approach links ophthalmic and cardiovascular expertise.
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