Juan Miguel B. B.
- Country
- Spain
- Department
- 172401: Hematologia
Research Overview
- Phase 1 Dose Escalation Study of SGR-2921 Monotherapy in Relapsed/Refractory Acute Myeloid Leukemia and Myelodysplastic Syndrome
- Phase 1 Open-Label Dose Escalation and Expansion Study of CLN-049 in Acute Myeloid Leukemia with Measurable Residual Disease
- A Phase 2 Open-label Study of Loncastuximab Tesirine in Combination with Rituximab (Lonca-R) in Previously Untreated Unfit/Frail Patients with Diffuse Large B-cell Lymphoma (DLBCL) (LOTIS-9)
Data & Insights
Has run more than one trial at 317 of 516 partner sites.
Specializations
Hematologic malignancies
Clinical activity is strongly centered on acute myeloid leukemia, acute lymphoblastic leukemia, myelodysplastic syndromes, multiple myeloma, and lymphoma, with additional involvement in chronic lymphocytic leukemia, mantle cell lymphoma, follicular lymphoma, and diffuse large B-cell lymphoma.
- Acute leukemia
- Plasma cell disorders
- B-cell and T-cell lymphomas
- Myelodysplastic and myeloproliferative diseases
The portfolio also includes cell therapy and other advanced approaches for relapsed or refractory blood cancers, reflecting a clear focus on treatment-resistant hematologic disease.
Breast and gynecologic oncology
A major therapeutic emphasis is placed on breast cancer, especially hormone receptor-positive, HER2-negative, HER2-positive, and triple-negative breast cancer, across early, locally advanced, and metastatic settings.
- Advanced breast cancer
- Triple-negative breast cancer
- Ovarian cancer
- Endometrial cancer
Research involvement extends to ovarian, endometrial, and gastroesophageal junction cancers, with repeated attention to biomarker-defined disease and metastatic progression.
Thoracic and solid tumors
The investigator is actively involved in studies of non-small cell lung cancer, small cell lung cancer, head and neck squamous cell carcinoma, renal cell carcinoma, and urothelial carcinoma, as well as broader solid tumors.
- Non-small cell lung cancer
- Renal cell carcinoma
- Urothelial carcinoma
- Head and neck cancer
Additional work spans melanoma, pancreatic cancer, gastric cancer, and colorectal cancer, showing broad engagement across advanced solid malignancies.
Autoimmune and inflammatory diseases
Research interests include systemic lupus erythematosus, psoriatic arthritis, Crohn's disease, ulcerative colitis, and Behçet's disease, together with other immune-mediated disorders.
- Systemic autoimmune disease
- Inflammatory bowel disease
- Psoriatic arthritis
- Vasculitis and cytopenias
There is also involvement in immune thrombocytopenia, autoimmune hemolytic anemia, and chronic graft-versus-host disease, indicating a therapeutic interest in immune dysregulation and its complications.
Cardiometabolic, pulmonary, and neurological disorders
The clinical landscape also covers cardiovascular disease, heart failure, atrial fibrillation, atherosclerotic disease, and obesity, alongside chronic kidney disease and metabolic liver disease.
- Cardiovascular disease
- Chronic kidney disease
- Metabolic dysfunction-associated steatohepatitis
- Parkinson's disease and migraine
Additional involvement includes asthma, chronic obstructive pulmonary disease, pulmonary fibrosis, migraine, schizophrenia, and Alzheimer's disease, reflecting a wide therapeutic reach beyond oncology and hematology.
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