Juan Manuel S. S.
- Country
- Spain
- Department
- Neurooncología
Research Overview
- ONC201 for the Treatment of Newly Diagnosed H3 K27M-mutant Diffuse Glioma Following Completion of Radiotherapy: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Study (The ACTION Study)
- Dose-Escalation Study of [177Lu]Lu-DOTA-TATE with Standard Care in Newly Diagnosed Glioblastoma and as Monotherapy in Recurrent Glioblastoma.
- Phase 1 Evaluation of HMPL-306 in Patients with IDH-Mutant Locally Advanced or Metastatic Solid Tumors, Including Cholangiocarcinoma, Chondrosarcoma, and Glioma
Data & Insights
Has run more than one trial at 58 of 114 partner sites.
Specializations
Thoracic and Head and Neck Oncology
Clinical research activity is strongly centered on advanced non-small cell lung cancer, small cell lung cancer, and head and neck squamous cell carcinoma, with additional involvement in biomarker-defined thoracic malignancies and recurrent or metastatic disease.
- Non-small cell lung cancer
- Small cell lung cancer
- Head and neck squamous cell carcinoma
- EGFR-mutated lung cancer
- ALK- and RET-altered solid tumors
Interest also extends to mesothelioma and other advanced solid tumors with actionable molecular alterations.
Breast, Gynecologic, and Urologic Cancers
The investigator is active in breast cancer research across hormone receptor-positive, HER2-negative, HER2-positive, and triple-negative settings, together with ovarian cancer, endometrial cancer, cervical cancer, and urothelial carcinoma.
- Hormone receptor-positive breast cancer
- Triple-negative breast cancer
- Ovarian cancer
- Endometrial cancer
- Urothelial carcinoma
Research also includes biliary tract cancer and other advanced genitourinary and gynecologic malignancies.
Hematologic Malignancies
There is substantial involvement in trials for lymphoma, multiple myeloma, and acute myeloid leukemia, including both aggressive and indolent B-cell disorders as well as myeloid neoplasms.
- Diffuse large B-cell lymphoma
- Follicular lymphoma
- Multiple myeloma
- Acute myeloid leukemia
- Myelodysplastic syndromes
Additional activity covers mantle cell lymphoma, chronic lymphocytic leukemia, and myelofibrosis.
Neuro-Oncology and Central Nervous System Tumors
Within the Neurooncology Unit, the investigator is involved in studies of glioblastoma, glioma, and other primary brain tumors, with attention to recurrent, unresectable, and molecularly defined disease.
- Glioblastoma
- Low-grade glioma
- IDH-mutant glioma
- Diffuse glioma
- Brain metastases
Research also includes meningioma and selected ependymal and spinal cord tumors.
Targeted Therapy and Biomarker-Driven Solid Tumors
The clinical portfolio includes advanced solid tumors selected by molecular alterations, with interest in KRAS, HER2, BRAF, PIK3CA, FGFR, and MTAP-associated disease.
- KRAS-mutated solid tumors
- HER2-expressing cancers
- BRAF-altered malignancies
- PIK3CA-mutated breast cancer
- FGFR-altered urothelial and solid tumors
These activities include precision oncology approaches across advanced and metastatic cancer settings.
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