Juan Jesús M. L.
- Country
- Spain
- Department
- Oncology
Research Overview
Data & Insights
Has run more than one trial at 3 of 20 partner sites.
Specializations
Hematologic Malignancies
The investigator focuses on diseases of the blood and marrow, including acute myeloid leukemia, myelodysplastic syndrome, chronic lymphocytic leukemia, and multiple myeloma.
- acute myeloid leukemia
- myelodysplastic syndrome
- chronic lymphocytic leukemia
- multiple myeloma
- mantle cell lymphoma
- follicular lymphoma
- Waldenstrom macroglobulinemia
Research includes both newly diagnosed and relapsed/refractory settings.
Solid Tumor Oncology
Extensive work across major solid tumors such as breast cancer, non‑small cell lung cancer, colorectal cancer, pancreatic cancer, and renal cell carcinoma.
- breast cancer
- non‑small cell lung cancer
- colorectal cancer
- pancreatic cancer
- renal cell carcinoma
- hepatocellular carcinoma
- melanoma
- glioblastoma
- urothelial carcinoma
- ovarian cancer
Emphasis is placed on advanced, metastatic and unresectable disease stages.
Targeted Molecular Therapies
Investigates therapies directed at specific genomic alterations, including KRAS G12C mutation, HER2‑positive tumors, EGFR exon 20 insertion, and IDH1 mutation.
- KRAS G12C mutation
- HER2‑positive tumors
- EGFR exon 20 insertion
- IDH1 mutation
- BRAF V600E mutation
- ALK rearrangement
- PIK3CA mutation
Studies often involve biomarker‑selected patient cohorts.
Immuno‑Oncology
Engages in trials evaluating checkpoint inhibition and cellular immunotherapies across multiple cancer types, such as PD‑1 inhibitor, CTLA‑4 inhibitor, CAR‑T cell therapy and bispecific antibodies.
- PD‑1 blockade
- CTLA‑4 blockade
- CAR‑T cell therapy
- bispecific antibodies
Applications span both hematologic and solid malignancies.
Transplant and Cellular Therapies
Focuses on allogeneic hematopoietic stem cell transplantation and related complications such as graft‑versus‑host disease and post‑transplant anemia.
- allogeneic stem cell transplant
- graft‑versus‑host disease
- post‑transplant anemia
- transplant‑associated thrombotic microangiopathy
Includes supportive care strategies to improve transplant outcomes.
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